THE EFFECT OF Pepper Nigrum, Olea Europaea MOUTHWASH WITH NON SURGICAL PERIODONTAL THERAPY ON CLINICAL OUTCOME AND OXIDATIVE STRESS IN CHRONIC PERIODONTITIS PATIENTS
Abstract
Introduction: gargles are liquid topical drugs that action by gargling and rinsing into mouth. Many mouthwashes are existences and by prescription with a broad level of active components which can be manipulated as a helper to aid in the multifactorial therapy of complicated oral situation , consisting of gingivitis, halitosis, and periodontal illness. Newly ( Pepper Nigrum , Olea Europaea ) are herbal with antibacterial, anti-inflammatory, antioxidant and antifungal influences, using plant extracts as mouthwash , in addition to being safe and inexpensive.
Aim :To measure the effect of herbal mouthwash (Pepper Nigrum , Olea Europaea) and non-surgical periodontal therapy in comparison with periodontal therapy alone on oxidative stress , total antioxidant capacity , antioxidant enzyme activities in all spit of sick person with chronic periodontitis. To investigate association amidst oxidative stress parameter, antioxidant enzymes, total antioxidant capacity and periodontal parameter
Material and ways : A flow up study was conducted on a randomly selected sample of 72 patients (39male and 33femal) aged 25-55 years from patients attending college of dentistry ,department of periodontology from December 2020, to April 2020 .participants were assigned into three categories , every catigory consist of 24 patients : first group receiving non-surgical periodontal treatment NSPT and Pepper Nigrum mouthwash, second groups receiving Olea Europaea and NSPT while the third group control receiving NSPT only. Clinical attachment loss (CAL) and Plaque Index (PI) were recorded. Salivary oxidative stress eight hydroxy deoxyguanosine (8-OHdG),salivary Catalase(CAT) and salivary Total antioxidant capacity (TAOC), were measured
Result : The concentration of salivary antioxidants (CAT) significantly increase p-value <0.006, the periodontal parameter (CAL , PI) and oxidative stress 8-OHdG significantly decrease p-value <0.0001 and <0.001 respectively after two weeks following the NSPT in group of Pepper Nigrum, while TAOC was not changed .Moreover, for Olea Europaea group the clinical parameters of CAL, PI showed a significant decrease and p-value was (P<0.0001) .Also CAT and TAOC express a significant increase (P<0.0001) .In addition to oxidative stress 8-OHdG marker showed a significant decrease (p <0.0001)
Conclusion: According to our research, Pepper Nigrum, Olea Europaea mouthwash with NSPT reduced OS and bettering periodontal status and elevated salivary antioxidant . So, it is advised that Pepper Nigrum , Olea Europaea mouthwash with NSPT could be further efficient in control of inflammation in sick people with CP positive and negative correlations were found between biochemical and clinical parameters in Pepper Nigrum group while more positive correlation was found in Olea Europaea group. It indicates that periodontitis can be one of the factors for decreased antioxidant level in our body. It indicates that periodontitis can be one of the factors for decreased antioxidant level in our body
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