ALPHA- SMOOTH MUSCLE ACTIN EXPRESSION IN THE HUMAN DENTAL PULP TISSUE OF MOBILE TEETH
Tooth mobility is a degree of tooth looseness in its bony socket. A slight degree is accepted as a normal physiologic mobility of all types of the teeth in the oral cavity. During the tooth mobility due to different causes several biological processes take place, during these biological processes the dental pulp tissue is subjected to structural and protein expression modifications in order to maintain their integrity and functional morphology. The aim of this study is to evaluate Alpha- smooth muscle actin expression in the human dental pulp tissue of mobile teeth.Method: Acrosssectional study of 66 extracted teeth with their pulp tissue (49 with mobility and 17 as non-mobile control group); the samples were processed, and the immunohistochemicalreaction of the Alpha- smooth muscle actin (α-SMA) marker for each sample were analyzed.Results: Among the mobile teeth group (29) were with mild to moderate mobility, (20) with sever mobility. The Alpha- smooth muscle actin (α-SMA) positive results were obtained in (7) samples of the teeth with sever mobility and (21) samples of teeth with mild to moderate mobility were compared to (9) positive cases of control group. Conclusion: The data demonstrate that the dental pulp tissue does not expresses any irreversible histological alterations with mild to moderate teeth mobility compared to the irreversible changes that obtained in the pulp tissue of the sever mobile group. In conclusion the type of treatment required for the mobile teeth will depend on the responses of the pulp and the supporting periapical tissues to determine the outcome of the involved teeth sequel
Baker, A., Karpagaselvi, K., Kumaraswamy, J., Ranjini, M. R., &Gowher, J. (2019). Role of dental pulp in age estimation: A quantitative and morphometric study. Journal of forensic dental sciences, 11(2), 95.
Bondjers, C., Kalén, M., Hellström, M., Scheidl, S. J., Abramsson, A., Renner, O., ...&Betsholtz, C. (2003). Transcription profiling of platelet-derived growth factor-Bdeficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells. The American journal of pathology, 162(3), 721-729.
Catón, J., Bostanci, N., Remboutsika, E., De Bari, C., &Mitsiadis, T. A. (2011). Future dentistry: cell therapy meets tooth and periodontal repair and regeneration. Journal of cellular and molecular medicine, 15(5), 1054-1065.
Chen, J., Yang, P., Xiao, Y., Zhang, Y., Liu, J., Xie, D., ...& Zhang, X. (2017).
Overexpression of α-sma-positive fibroblasts (CAFs) in nasopharyngeal carcinoma predicts poor prognosis. Journal of Cancer, 8(18), 3897.
Colombo, J. S., Moore, A. N., Hartgerink, J. D., & D’Souza, R. N. (2014). Scaffolds to control inflammation and facilitate dental pulp regeneration.Journal of endodontics, 40(4), S6-S12.
Darby, I. A., Laverdet, B., Bonté, F., &Desmoulière, A. (2014). Fibroblasts and myofibroblasts in wound healing. Clinical, cosmetic and investigational dermatology, 7, 301.
Etienne‐Manneville, S. (2004). Actin and microtubules in cell motility: which one is in control?. Traffic, 5(7), 470-477.
Garg, N., &Garg, A. (2010).Textbook of endodontics.Boydell& Brewer Ltd.
Graves, D. T., Oates, T., &Garlet, G. P. (2011). Review of osteoimmunology and the host response in endodontic and periodontal lesions. Journal of oral microbiology, 3(1), 5304.
Hinz, B., Phan, S. H., Thannickal, V. J., Prunotto, M., Desmoulière, A., Varga, J., ...&Gabbiani, G. (2012). Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. The American journal of pathology, 180(4), 1340-1355. 12.Ibraheem, S. N., &Yalda, M. I. (2018). Protease-Activated Receptors 2 and AlphaSmooth Muscle Actin Expression in the Pulp Tissue of Caries Teeth. International Journal of Medical Research & Health Sciences, 7(7), 47-53.
Meng, Y., Han, X., Huang, L., Bai, D., Yu, H., He, Y., & Jing, Y. (2010). Orthodontic mechanical tension effects on the myofibroblast expression of alpha-smooth muscle actin. The Angle Orthodontist, 80(5), 912-918.
Rodrigues, M., Kosaric, N., Bonham, C. A., &Gurtner, G. C. (2019). Wound healing: a cellular perspective. Physiological reviews, 99(1), 665-706.
SAJID, T. (2020).Periodontal splinting a review. European Journal of Molecular & Clinical Medicine, 7(3), 2000-2005.
Yu, C. Y., & Abbott, P. V. (2016).Responses of the pulp, periradicular and soft tissues following trauma to the permanent teeth.Australian dental journal, 61, 39-58.
It is the policy of the Journal of Duhok University to own the copyright of the technical contributions. It publishes and facilitates the appropriate re-utilize of the published materials by others. Photocopying is permitted with credit and referring to the source for individuals use.
Copyright © 2017. All Rights Reserved.