THE EFFECT OF NON-SURGICAL PERIODONTAL THERAPY ON PERIODONTAL PARAMETERS, MALONDIALDEHYDE, TOTAL OXIDANT STATUS AND ANTIOXIDANT CAPACITY IN SMOKERS WITH CHRONIC PERIODONTITIS
Keywords:
Periodontitis, Oxidative Stress Markers, Antioxidant, Smoking, Scaling & Root Planing
Abstract
BACKGROUND AND OBJECTIVE: Oxidative stress can be described as a state brought on by an unfavorable rise in the generation of reactive oxygen species (ROS), a growth in ROS production, or a decline in antioxidant defense. The study aimed to investigate the impact of non-surgical periodontal treatment on clinical periodontal parameters and serum malondialdehyde MDA, total antioxidant capacity TAOC, and total oxidant status TOS in smokers and non-smokers periodontitis patients.
METHODS: A clinical comparative research was carried out on 60 systemically healthy subjects with an average age of 30-50 years; 30 with chronic periodontitis (15 non-smoker periodontitis NSP and 15 smoker periodontitis SP) and 30 with healthy periodontium (15 non-smoker healthy NSH and 15 smoker healthy SH). Blood samples and clinical periodontal parameters were collected at baseline before scaling & root planing SRP and after six weeks of treatment to estimate MDA, TOS, and TAOC.
RESULTS: Clinical periodontal parameters (PI,GI,BOP,PPD&CAL) and oxidative stress markers (MDA and TOS) were significantly reduced after SRP for periodontitis patients groups(smoker periodontitis SP and non-smoker periodontitis NSP) the non-significant reduction of gingival recession GR and non-significant elevation of TAOC (P>0.05 ). However, no correlation was found between biochemical and clinical parameters at baseline and after therapy, except for the significant negative correlation between BOP and TAOC in SP and between TAOC & PPD in NSP before therapy.
CONCLUSION: Non-surgical periodontal therapy could significantly improve clinical periodontal parameters, reduce oxidative stress and improve the antioxidant defense system of the body
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Ahmadkhaniha R., Yousefian F., and Rastikari N.(2021).Impact of smoking on oxidant/ antioxidant status and oxidative stress index levels in serum of the university students. Journal of Environmental Health Science and Engineering ,19,1043-6.
Ainamo, J. and Bay, I. (1975). Problems and proposals for recording gingivitis and plaque. International Dental Journal, 25, 229–35.
Akalin, F.A., Baltacioğlu, E., Alver, A. and Karabulut, E. (2007). Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. Journal of Clinical Periodontology, 34, 558–65.
Akpinar, A., Toker, H., Ozdemir, H., Bostanci, V. and Aydin, H. (2013). The effects of non-surgical periodontal therapy on oxidant and anti-oxidant status in smokers with chronic periodontitis. Archives of Oral Biology, 58, 717–23.
Akram, Z., Shafqat, S.S., Niaz, M.O., Raza, A. and Naseem, M. (2020). Clinical efficacy of photodynamic therapy and laser irradiation as an adjunct to open flap debridement in the treatment of chronic periodontitis: A systematic review and meta-analysis. Photodermatology, Photoimmunology & Photomedicine, 36, 3–13.
Al-Katma, M.K., Bissada, N.F., Bordeaux, J.M., Sue, J. and Askari, A.D. (2007). Control of periodontal infection reduces the severity of active rheumatoid arthritis. Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases, 13, 134–7.
Altuntaş, I., Dane, S. and Gümüştekin, K. (2002). Effects of cigarette smoking on lipid peroxidation. Journal of Basic and Clinical Physiology and Pharmacology, 13, 69–72.
Amarasena, N., Ekanayaka, A.N.I., Herath, L. and Miyazaki, H. (2002). Tobacco use and oral hygiene as risk indicators for periodontitis. Community Dentistry and Oral Epidemiology, 30, 115–23.
Aslan, R., Kutlu, R., Civi, S. and Tasyurek, E. (2014). The correlation of the total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase activity (PON1) with smoking. Clinical Biochemistry, 47, 393–7.
Aziz, A., Madhav, G., Kalekar, T., Benjamin, A., Suryakar, M., Prakashan, M., Nadeem, A. and Bijle, M.N. (2013). Effect of Nonsurgical Periodontal Therapy on Some Oxidative Stress Markers in Patients with Chronic Periodontitis: A Biochemical Study. World Journal of Dentistry, 4, 17–23.
Badersten, A., Nilveus, R. and Egelberg, J. (1984). Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. Journal of Clinical Periodontology, 11, 63–76.
Baltacıoğlu, E., Kehribar, M.A., Yuva, P., Alver, A., Atagün, Ö.S., Karabulut, E. and Akalın, F.A. (2014). Total Oxidant Status and Bone Resorption Biomarkers in Serum and Gingival Crevicular Fluid of Patients with Periodontitis. Journal of Periodontology, 85, 317–26.
Bansal, N., Gupta, Narinder, Bey, A., Sharma, V., Gupta, Namita and Trivedi, H. (2018). Impact of nonsurgical periodontal therapy on total antioxidant capacity in chronic periodontitis patients. Journal of Indian Society of Periodontology, 21, 291-5.
Bansal, N., Gupta, N.D., Bey, A., Sharma, V.K., Gupta, N. and Trivedi, H. (2017). Impact of nonsurgical periodontal therapy on total antioxidant capacity in chronic periodontitis patients. Journal of Indian Society of Periodontology, 21, 291–5.
Baser, U., Gamsiz-Isik, H., Cifcibasi, E., Ademoglu, E. and Yalcin, F. (2015). Plasma and salivary total antioxidant capacity in healthy controls compared with aggressive and chronic periodontitis patients. Saudi Medical Journal, 36, 856–61.
Batenhorst, K.F., Bowers, G.M. and Williams, J.E. (1974). Tissue changes resulting from facial tipping and extrusion of incisors in monkeys. Journal of Periodontology, 45, 660–8.
Bergström, J. and Boström, L. (2001). Tobacco smoking and periodontal hemorrhagic responsiveness. Journal of Clinical Periodontology, 28, 680–5.
Brock, G.R., Butterworth, C.J., Matthews, J.B. and Chapple, I.L.C. (2004). Local and systemic total antioxidant capacity in periodontitis and health. Journal of Clinical Periodontology, 31, 515–21.
Chapple, I.L.C., Brock, G., Eftimiadi, C. and Matthews, J.B. (2002). Glutathione in gingival crevicular fluid and its relation to local antioxidant capacity in periodontal health and disease. Molecular Pathology, 55, 367–73.
Chapple, I.L.C., Brock, G.R., Milward, M.R., Ling, N. and Matthews, J.B. (2007). Compromised GCF total antioxidant capacity in periodontitis: cause or effect? Journal of Clinical Periodontology, 34, 103–10.
Collins, A.R. (2005). Assays for oxidative stress and antioxidant status: applications to research into the biological effectiveness of polyphenols. The American Journal of Clinical Nutrition, 81, 261-7.
Dietrich, T., Bernimoulin, J.-P. and Glynn, R.J. (2004). The effect of cigarette smoking on gingival bleeding. Journal of Periodontology, 75, 16–22.
Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry, 38, 1103–11.
Gadham, J. and Prasanna, M.L. (2017). A Comparative Study of Serum Total Antioxidant Capacity (TAC) in Male Smokers and Non Smokers. International Journal of Physiology, 5, 18-24.
Garg, N., Singh, R., Dixit, J., Jain, A. and Tewari, V. (2006).Levels of lipid peroxides and antioxidants in smokers and nonsmokers. Journal of Periodontal Research, 41, 405–10.
Gautam, D.K., Jindal, V., Gupta, S.C., Tuli, A., Kotwal, B. and Thakur, R. (2011). Effect of cigarette smoking on the periodontal health status: A comparative, cross sectional study. Journal of Indian Society of Periodontology, 15, 383–7.
Genco, R.J. and Borgnakke, W.S. (2013). Risk factors for periodontal disease: Risk factors for periodontal diseases. Periodontology 2000, 62, 59–94.
Gloria Calsina, Ramón, J.-M. and Echeverría, J.-J. (2002).Effects of smoking on periodontal tissues: Effects of smoking on periodontal tissues. Journal of Clinical Periodontology, 29, 771–6.
Grant, M.M., Brock, G.R., Matthews, J.B. and Chapple, I.L.C. (2010).Crevicular fluid glutathione levels in periodontitis and the effect of non-surgical therapy. Journal of Clinical Periodontology, 37, 17–23.
Guentsch, A., Preshaw, Philip M., Bremer-Streck, S., Klinger, G., Glockmann, E. and Sigusch, B.W. (2008). Lipid peroxidation and antioxidant activity in saliva of periodontitis patients: effect of smoking and periodontal treatment. Clinical Oral Investigations, 12, 345–52.
Haffajee, A.D. and Socransky, S.S. (2001a). Relationship of cigarette smoking to attachment level profiles. Journal of Clinical Periodontology, 28, 283–95.
Haffajee, A.D. and Socransky, S.S. (2001b). Relationship of cigarette smoking to the subgingival microbiota. Journal of Clinical Periodontology, 28, 377–88.
Haffajee, A.D. and Socransky, S.S. (2001c). Relationship of cigarette smoking to the subgingival microbiota: Smoking and subgingival plaque. Journal of Clinical Periodontology, 28, 377–88.
Heitz‐Mayfield, L. J. A. (2005). Disease progression: identification of high‐risk groups and individuals for periodontitis. Journal of clinical periodontology, 32, 196-209.
Ho, Y.-C. and Chang, Y.-C. (2006). Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. Acta Pharmacologica Sinica, 27, 409–13.
Hughes, T.P. and Caffesse, R.G. (1978). Gingival Changes Following Scaling, Root Planing and Oral Hygiene—A Biometric Evaluation. Journal of Periodontology, 49, 245–52.
Johnson, G.K. and Guthmiller, J.M. (2007). The impact of cigarette smoking on periodontal disease and treatment. Periodontology 2000, 44, 178–94.
Kahnamoei, J. R., Maleki, F., Nasirzadeh, M. R., & Kishizadeh, F. (2014). The effects of cigarette smoking on plasma MDA and TAC in university students. Bulletin of Environment, Pharmacology and Life Sciences, 3, 95-8.
Kassebaum, N.J., Bernabé, E., Dahiya, M., Bhandari, B., Murray, C.J.L. and Marcenes, W. (2014). Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. Journal of Dental Research, 93, 1045–53.
Karring, T., Lang, N.P. and Löe, H. (1975). The role of gingival connective tissue in determining epithelial differentiation. Journal of Periodontal Research, 10, 1–11.
Kaufman, E. and Lamster, I.B. (2000). Analysis of saliva for periodontal diagnosis--a review. Journal of Clinical Periodontology, 27, 453–65.
Kaufmann, M.E., Wiedemeier, D.B., Zellweger, U., Solderer, A., Attin, T. and Schmidlin, P.R. (2020). Gingival recession after scaling and root planing with or without systemic metronidazole and amoxicillin: a re-review. Clinical Oral Investigations, 24, 1091–100.
Könönen, E., Gursoy, M. and Gursoy, U.K. (2019). Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues. Journal of Clinical Medicine, 8, 1135.
Konuganti, K., Seshan, H., Zope, S. and Silvia, W.D. (2012). A comparative evaluation of whole blood total antioxidant capacity using a novel nitroblue tetrazolium reduction test in patients with periodontitis and healthy subjects: A randomized, controlled trial. Journal of Indian Society of Periodontology, 16, 620–2.
Kumar, C.N., Rao, S.M., Shetty, P.R., Ranganath, V., Patil, A.S. and John, A.A. (2019). Salivary antioxidant enzymes and lipid peroxidation product malondialdehyde and sialic acid levels among smokers and non-smokers with chronic periodontitis—A clinico-biochemical study. Journal of Family Medicine and Primary Care, 8, 2960-4.
Kurku, H., Kacmaz, M., Kisa, U., Dogan, O. and Caglayan, O. (2015). Acute and chronic impact of smoking on salivary and serum total antioxidant capacity. Journal of the Pakistan Medical Association, 65, 164-9.
Lindhe, J., Lang, N.P. and Karring, T. (2008). Clinical periodontology and implant dentistry. Oxford; Ames, Iowa: Blackwell Munksgaard.
Loe, H. and Silness, J. (1963). Periodontal Disease in Pregnancy. I. Prevalence and Severity. Acta Odontologica Scandinavica, 21, 533–51.
Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy reviews, 4(8), 118.
Luzzi, L.I.T., Greghi, S.L.A., Passanezi, E., Sant’ana, A.C.P., Lauris, J.R.P. and Cestari, T.M. (2007). Evaluation of clinical periodontal conditions in smokers and non-smokers. Journal of Applied Oral Science, 15, 512–7.
Machuca, G., Rosales, I., Lacalle, J.R., Machuca, C. and Bullón, P. (2000). Effect of cigarette smoking on periodontal status of healthy young adults. Journal of Periodontology, 71, 73–8.
Marcaccini, A.M., Meschiari, C.A., Zuardi, L.R., de Sousa, T.S., Taba, M., Teofilo, J.M., Jacob-Ferreira, A.L.B., Tanus-Santos, J.E., Novaes, A.B. and Gerlach, R.F. (2010). Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy. Journal of Clinical Periodontology, 37, 180–90.
Markkanen, H., Paunio, I., Tuominen, R. and Rajala, M. (1985). Smoking and periodontal disease in the Finnish population aged 30 years and over. Journal of Dental Research, 64, 932–5.
Müller, H.-P., Stadermann, S. and Heinecke, A. (2002). Gingival recession in smokers and non-smokers with minimal periodontal disease. Journal of Clinical Periodontology, 29, 129–36.
Nandhana, S., Gurunathan, D. and Thamaraiselvan, M. (2019). Prevalence of gingival recession in smokers and non-smokers - A cross-sectional study. Drug Invention Today, 12, 380-3.
Newman, M.G., Takei, H., Klokkevold, P.R. and Carranza, F.A. (2014). Carranza’s Clinical Periodontology - E-Book: Expert Consult: Online. Elsevier Health Sciences.
Nociti, F.H., Casati, M.Z. and Duarte, P.M. (2015). Current perspective of the impact of smoking on the progression and treatment of periodontitis. Periodontology 2000, 67, 187–210.
Nsonwu-Anyanwu, A., Offor, S., & John, I. (2018). Cigarette smoke and oxidative stress indices in male active smokers. Reactive Oxygen Species, 5, 199-208.
Önder, C., Kurgan, Ş., Altıngöz, S.M., Bağış, N., Uyanık, M., Serdar, M.A., Kantarcı, A. and Günhan, M. (2017). Impact of non-surgical periodontal therapy on saliva and serum levels of markers of oxidative stress. Clinical Oral Investigations, 21, 1961–9.
Pejčić, A., Obradović, R., Kesić, L., & Kojović, D. (2007). Smoking and periodontal disease: A review. Medicine and Biology, 14, 53-9.
Pham-Huy, L.A., He, H. and Pham-Huy, C. (2008). Free Radicals, Antioxidants in Disease and Health. International Journal of Biomedical Science, 4, 89–96.
Preber, H. and Bergström, J. (1986). Cigarette smoking in patients referred for periodontal treatment. Scandinavian Journal of Dental Research, 94, 102–8.
Rao, P.S.S., Ande, A., Sinha, N., Kumar, A. and Kumar, S. (2016). Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells. PLOS ONE, 11, e0155791.
Reejamol, M.K. and Swaminathan, M. (2013). Estimation of lipid peroxides and antioxidants in smokers and non-smokers with periodontitis. King Saud University Journal of Dental Sciences, 4, 53–6.
Rudrakshi, C., Prabhuji, M. L. V., Parween, S., & Jyothsna, S. (2017). Relationship between antioxidants and the development of the periodontal disease. J. Cytol. Tissue Biol, 4, 16.
Mokeem, S. A., Vellappally, S., Preethanath, R. S., Hashem, M. I., Al-Kheraif, A. A., & Anil, S. (2014). Influence of smoking on clinical parameters and gingival crevicular fluid volume in patients with chronic periodontitis. Oral health and dental management, 13, 469-73.
Şentürk, R.A., Sezgin, Y., Bulut, Ş. and Özdemir, B.H. (2018). The effects of smoking on the expression of gelatinases in chronic periodontitis: a cross-sectional study. Brazilian Oral Research, 32, e114.
Shirzaiy, M., Aiub Rigi Ladiz, M., Dalirsani, Z., Dehghan Haghighi, J. and Nakhaii, A. (2017). Evaluation of Salivary Total Antioxidant Capacity in Smokers with Severe Chronic Periodontitis. International Journal of High Risk Behaviors and Addiction, 6, e59486.
Sies, H. (2007). Total antioxidant capacity: appraisal of a concept. The Journal of Nutrition, 137, 1493–5.
Silness, J., & Löe, H. (1964). Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta odontologica scandinavica, 22, 121-35.
Hrishi, T. S., Menon, S. K., Kundapur, P., & Gupta, S. (2016). Comparative evaluation of GCF total antioxidant capacity in chronic periodontitis patients before and after non-surgical periodontal therapy. International Journal of Dental Research and Development, 6, 11-6.
Smiley, C.J., Tracy, S.L., Abt, E., Michalowicz, B.S., John, M.T., Gunsolley, J., Cobb, C.M., Rossmann, J., Harrel, S.K., Forrest, J.L., Hujoel, P.P., Noraian, K.W., Greenwell, H., Frantsve-Hawley, J., Estrich, C. and Hanson, N. (2015). Evidence-based clinical practice guideline on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. The Journal of the American Dental Association, 146, 525–35.
Söder, B., Nedlich, U. and Jin, L.J. (1999). Longitudinal Effect of Non-Surgical Treatment and Systemic Metronidazole for 1 Week in Smokers and Non-Smokers with Refractory Periodontitis: A 5-Year Study. Journal of Periodontology, 70, 761–71.
Sreedevi, M., Ramesh, A. and Dwarakanath, C. (2012). Periodontal Status in Smokers and Nonsmokers: A Clinical, Microbiological, and Histopathological Study. International Journal of Dentistry, 2012, 571-90.
Taba, M., Kinney, J., Kim, A.S. and Giannobile, W.V. (2005). Diagnostic biomarkers for oral and periodontal diseases. Dental Clinics of North America, 49, 551–571.
Talari, A. and Ainamo, J. (1976). Orthopantomographic assessment of the width of attached gingiva. Journal of Periodontal Research, 11, 177–81.
Taylor, G.W. and Borgnakke, W.S. (2008). Periodontal disease: associations with diabetes, glycemic control and complications. Oral Diseases, 14, 191–203.
Theodoro, L.H., Assem, N.Z., Longo, M., Alves, M.L.F., Duque, C., Stipp, R.N., Vizoto, N.L. and Garcia, V.G. (2018). Treatment of periodontitis in smokers with multiple sessions of antimicrobial photodynamic therapy or systemic antibiotics: A randomized clinical trial. Photodiagnosis and Photodynamic Therapy, 22, 217–22.
Thomas, B., Madani, S.M., Prasad, B.R. and Kumari, S. (2014). Comparative evaluation of serum antioxidant levels in periodontally diseased patients: An interventional study. Contemporary Clinical Dentistry, 5, 340–4.
Tsai, C.C., Chen, H.S., Chen, S.L., Ho, Y.P., Ho, K.Y., Wu, Y.M. and Hung, C.C. (2005). Lipid peroxidation: a possible role in the induction and progression of chronic periodontitis. Journal of Periodontal Research, 40, 378–84.
Visvanathan, R., Mahendra, J., N, A., Pandisuba and Chalini (2014). Effect of Smoking on Periodontal Health. Journal of Clinical and Diagnostic Research : JCDR, 8, 46–9.
Wei, D., Zhang, X.-L., Wang, Y.-Z., Yang, C.-X. and Chen, G. (2010). Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy. Australian Dental Journal, 55, 70–8.
Zhang, T., Andrukhov, O., Haririan, H., Müller-Kern, M., Liu, S., Liu, Z. and Rausch-Fan, X. (2016). Total Antioxidant Capacity and Total Oxidant Status in Saliva of Periodontitis Patients in Relation to Bacterial Load. Frontiers in Cellular and Infection Microbiology. Retrieved August 6, 2022, fromhttps://www.frontiersin.org/article/10.3389/fcimb.2015. 00097
Zhang, Y., He, J., He, B., Huang, R. and Li, M. (2019). Effect of tobacco on periodontal disease and oral cancer.Tobacco Induced Diseases, 17, 40.
Zhou, J., Olson, B.L. and Windsor, L.J. (2007). Nicotine increases the collagen-degrading ability of human gingival fibroblasts. Journal of Periodontal Research, 42, 228–35.
Ainamo, J. and Bay, I. (1975). Problems and proposals for recording gingivitis and plaque. International Dental Journal, 25, 229–35.
Akalin, F.A., Baltacioğlu, E., Alver, A. and Karabulut, E. (2007). Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. Journal of Clinical Periodontology, 34, 558–65.
Akpinar, A., Toker, H., Ozdemir, H., Bostanci, V. and Aydin, H. (2013). The effects of non-surgical periodontal therapy on oxidant and anti-oxidant status in smokers with chronic periodontitis. Archives of Oral Biology, 58, 717–23.
Akram, Z., Shafqat, S.S., Niaz, M.O., Raza, A. and Naseem, M. (2020). Clinical efficacy of photodynamic therapy and laser irradiation as an adjunct to open flap debridement in the treatment of chronic periodontitis: A systematic review and meta-analysis. Photodermatology, Photoimmunology & Photomedicine, 36, 3–13.
Al-Katma, M.K., Bissada, N.F., Bordeaux, J.M., Sue, J. and Askari, A.D. (2007). Control of periodontal infection reduces the severity of active rheumatoid arthritis. Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases, 13, 134–7.
Altuntaş, I., Dane, S. and Gümüştekin, K. (2002). Effects of cigarette smoking on lipid peroxidation. Journal of Basic and Clinical Physiology and Pharmacology, 13, 69–72.
Amarasena, N., Ekanayaka, A.N.I., Herath, L. and Miyazaki, H. (2002). Tobacco use and oral hygiene as risk indicators for periodontitis. Community Dentistry and Oral Epidemiology, 30, 115–23.
Aslan, R., Kutlu, R., Civi, S. and Tasyurek, E. (2014). The correlation of the total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase activity (PON1) with smoking. Clinical Biochemistry, 47, 393–7.
Aziz, A., Madhav, G., Kalekar, T., Benjamin, A., Suryakar, M., Prakashan, M., Nadeem, A. and Bijle, M.N. (2013). Effect of Nonsurgical Periodontal Therapy on Some Oxidative Stress Markers in Patients with Chronic Periodontitis: A Biochemical Study. World Journal of Dentistry, 4, 17–23.
Badersten, A., Nilveus, R. and Egelberg, J. (1984). Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. Journal of Clinical Periodontology, 11, 63–76.
Baltacıoğlu, E., Kehribar, M.A., Yuva, P., Alver, A., Atagün, Ö.S., Karabulut, E. and Akalın, F.A. (2014). Total Oxidant Status and Bone Resorption Biomarkers in Serum and Gingival Crevicular Fluid of Patients with Periodontitis. Journal of Periodontology, 85, 317–26.
Bansal, N., Gupta, Narinder, Bey, A., Sharma, V., Gupta, Namita and Trivedi, H. (2018). Impact of nonsurgical periodontal therapy on total antioxidant capacity in chronic periodontitis patients. Journal of Indian Society of Periodontology, 21, 291-5.
Bansal, N., Gupta, N.D., Bey, A., Sharma, V.K., Gupta, N. and Trivedi, H. (2017). Impact of nonsurgical periodontal therapy on total antioxidant capacity in chronic periodontitis patients. Journal of Indian Society of Periodontology, 21, 291–5.
Baser, U., Gamsiz-Isik, H., Cifcibasi, E., Ademoglu, E. and Yalcin, F. (2015). Plasma and salivary total antioxidant capacity in healthy controls compared with aggressive and chronic periodontitis patients. Saudi Medical Journal, 36, 856–61.
Batenhorst, K.F., Bowers, G.M. and Williams, J.E. (1974). Tissue changes resulting from facial tipping and extrusion of incisors in monkeys. Journal of Periodontology, 45, 660–8.
Bergström, J. and Boström, L. (2001). Tobacco smoking and periodontal hemorrhagic responsiveness. Journal of Clinical Periodontology, 28, 680–5.
Brock, G.R., Butterworth, C.J., Matthews, J.B. and Chapple, I.L.C. (2004). Local and systemic total antioxidant capacity in periodontitis and health. Journal of Clinical Periodontology, 31, 515–21.
Chapple, I.L.C., Brock, G., Eftimiadi, C. and Matthews, J.B. (2002). Glutathione in gingival crevicular fluid and its relation to local antioxidant capacity in periodontal health and disease. Molecular Pathology, 55, 367–73.
Chapple, I.L.C., Brock, G.R., Milward, M.R., Ling, N. and Matthews, J.B. (2007). Compromised GCF total antioxidant capacity in periodontitis: cause or effect? Journal of Clinical Periodontology, 34, 103–10.
Collins, A.R. (2005). Assays for oxidative stress and antioxidant status: applications to research into the biological effectiveness of polyphenols. The American Journal of Clinical Nutrition, 81, 261-7.
Dietrich, T., Bernimoulin, J.-P. and Glynn, R.J. (2004). The effect of cigarette smoking on gingival bleeding. Journal of Periodontology, 75, 16–22.
Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry, 38, 1103–11.
Gadham, J. and Prasanna, M.L. (2017). A Comparative Study of Serum Total Antioxidant Capacity (TAC) in Male Smokers and Non Smokers. International Journal of Physiology, 5, 18-24.
Garg, N., Singh, R., Dixit, J., Jain, A. and Tewari, V. (2006).Levels of lipid peroxides and antioxidants in smokers and nonsmokers. Journal of Periodontal Research, 41, 405–10.
Gautam, D.K., Jindal, V., Gupta, S.C., Tuli, A., Kotwal, B. and Thakur, R. (2011). Effect of cigarette smoking on the periodontal health status: A comparative, cross sectional study. Journal of Indian Society of Periodontology, 15, 383–7.
Genco, R.J. and Borgnakke, W.S. (2013). Risk factors for periodontal disease: Risk factors for periodontal diseases. Periodontology 2000, 62, 59–94.
Gloria Calsina, Ramón, J.-M. and Echeverría, J.-J. (2002).Effects of smoking on periodontal tissues: Effects of smoking on periodontal tissues. Journal of Clinical Periodontology, 29, 771–6.
Grant, M.M., Brock, G.R., Matthews, J.B. and Chapple, I.L.C. (2010).Crevicular fluid glutathione levels in periodontitis and the effect of non-surgical therapy. Journal of Clinical Periodontology, 37, 17–23.
Guentsch, A., Preshaw, Philip M., Bremer-Streck, S., Klinger, G., Glockmann, E. and Sigusch, B.W. (2008). Lipid peroxidation and antioxidant activity in saliva of periodontitis patients: effect of smoking and periodontal treatment. Clinical Oral Investigations, 12, 345–52.
Haffajee, A.D. and Socransky, S.S. (2001a). Relationship of cigarette smoking to attachment level profiles. Journal of Clinical Periodontology, 28, 283–95.
Haffajee, A.D. and Socransky, S.S. (2001b). Relationship of cigarette smoking to the subgingival microbiota. Journal of Clinical Periodontology, 28, 377–88.
Haffajee, A.D. and Socransky, S.S. (2001c). Relationship of cigarette smoking to the subgingival microbiota: Smoking and subgingival plaque. Journal of Clinical Periodontology, 28, 377–88.
Heitz‐Mayfield, L. J. A. (2005). Disease progression: identification of high‐risk groups and individuals for periodontitis. Journal of clinical periodontology, 32, 196-209.
Ho, Y.-C. and Chang, Y.-C. (2006). Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. Acta Pharmacologica Sinica, 27, 409–13.
Hughes, T.P. and Caffesse, R.G. (1978). Gingival Changes Following Scaling, Root Planing and Oral Hygiene—A Biometric Evaluation. Journal of Periodontology, 49, 245–52.
Johnson, G.K. and Guthmiller, J.M. (2007). The impact of cigarette smoking on periodontal disease and treatment. Periodontology 2000, 44, 178–94.
Kahnamoei, J. R., Maleki, F., Nasirzadeh, M. R., & Kishizadeh, F. (2014). The effects of cigarette smoking on plasma MDA and TAC in university students. Bulletin of Environment, Pharmacology and Life Sciences, 3, 95-8.
Kassebaum, N.J., Bernabé, E., Dahiya, M., Bhandari, B., Murray, C.J.L. and Marcenes, W. (2014). Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. Journal of Dental Research, 93, 1045–53.
Karring, T., Lang, N.P. and Löe, H. (1975). The role of gingival connective tissue in determining epithelial differentiation. Journal of Periodontal Research, 10, 1–11.
Kaufman, E. and Lamster, I.B. (2000). Analysis of saliva for periodontal diagnosis--a review. Journal of Clinical Periodontology, 27, 453–65.
Kaufmann, M.E., Wiedemeier, D.B., Zellweger, U., Solderer, A., Attin, T. and Schmidlin, P.R. (2020). Gingival recession after scaling and root planing with or without systemic metronidazole and amoxicillin: a re-review. Clinical Oral Investigations, 24, 1091–100.
Könönen, E., Gursoy, M. and Gursoy, U.K. (2019). Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues. Journal of Clinical Medicine, 8, 1135.
Konuganti, K., Seshan, H., Zope, S. and Silvia, W.D. (2012). A comparative evaluation of whole blood total antioxidant capacity using a novel nitroblue tetrazolium reduction test in patients with periodontitis and healthy subjects: A randomized, controlled trial. Journal of Indian Society of Periodontology, 16, 620–2.
Kumar, C.N., Rao, S.M., Shetty, P.R., Ranganath, V., Patil, A.S. and John, A.A. (2019). Salivary antioxidant enzymes and lipid peroxidation product malondialdehyde and sialic acid levels among smokers and non-smokers with chronic periodontitis—A clinico-biochemical study. Journal of Family Medicine and Primary Care, 8, 2960-4.
Kurku, H., Kacmaz, M., Kisa, U., Dogan, O. and Caglayan, O. (2015). Acute and chronic impact of smoking on salivary and serum total antioxidant capacity. Journal of the Pakistan Medical Association, 65, 164-9.
Lindhe, J., Lang, N.P. and Karring, T. (2008). Clinical periodontology and implant dentistry. Oxford; Ames, Iowa: Blackwell Munksgaard.
Loe, H. and Silness, J. (1963). Periodontal Disease in Pregnancy. I. Prevalence and Severity. Acta Odontologica Scandinavica, 21, 533–51.
Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy reviews, 4(8), 118.
Luzzi, L.I.T., Greghi, S.L.A., Passanezi, E., Sant’ana, A.C.P., Lauris, J.R.P. and Cestari, T.M. (2007). Evaluation of clinical periodontal conditions in smokers and non-smokers. Journal of Applied Oral Science, 15, 512–7.
Machuca, G., Rosales, I., Lacalle, J.R., Machuca, C. and Bullón, P. (2000). Effect of cigarette smoking on periodontal status of healthy young adults. Journal of Periodontology, 71, 73–8.
Marcaccini, A.M., Meschiari, C.A., Zuardi, L.R., de Sousa, T.S., Taba, M., Teofilo, J.M., Jacob-Ferreira, A.L.B., Tanus-Santos, J.E., Novaes, A.B. and Gerlach, R.F. (2010). Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy. Journal of Clinical Periodontology, 37, 180–90.
Markkanen, H., Paunio, I., Tuominen, R. and Rajala, M. (1985). Smoking and periodontal disease in the Finnish population aged 30 years and over. Journal of Dental Research, 64, 932–5.
Müller, H.-P., Stadermann, S. and Heinecke, A. (2002). Gingival recession in smokers and non-smokers with minimal periodontal disease. Journal of Clinical Periodontology, 29, 129–36.
Nandhana, S., Gurunathan, D. and Thamaraiselvan, M. (2019). Prevalence of gingival recession in smokers and non-smokers - A cross-sectional study. Drug Invention Today, 12, 380-3.
Newman, M.G., Takei, H., Klokkevold, P.R. and Carranza, F.A. (2014). Carranza’s Clinical Periodontology - E-Book: Expert Consult: Online. Elsevier Health Sciences.
Nociti, F.H., Casati, M.Z. and Duarte, P.M. (2015). Current perspective of the impact of smoking on the progression and treatment of periodontitis. Periodontology 2000, 67, 187–210.
Nsonwu-Anyanwu, A., Offor, S., & John, I. (2018). Cigarette smoke and oxidative stress indices in male active smokers. Reactive Oxygen Species, 5, 199-208.
Önder, C., Kurgan, Ş., Altıngöz, S.M., Bağış, N., Uyanık, M., Serdar, M.A., Kantarcı, A. and Günhan, M. (2017). Impact of non-surgical periodontal therapy on saliva and serum levels of markers of oxidative stress. Clinical Oral Investigations, 21, 1961–9.
Pejčić, A., Obradović, R., Kesić, L., & Kojović, D. (2007). Smoking and periodontal disease: A review. Medicine and Biology, 14, 53-9.
Pham-Huy, L.A., He, H. and Pham-Huy, C. (2008). Free Radicals, Antioxidants in Disease and Health. International Journal of Biomedical Science, 4, 89–96.
Preber, H. and Bergström, J. (1986). Cigarette smoking in patients referred for periodontal treatment. Scandinavian Journal of Dental Research, 94, 102–8.
Rao, P.S.S., Ande, A., Sinha, N., Kumar, A. and Kumar, S. (2016). Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells. PLOS ONE, 11, e0155791.
Reejamol, M.K. and Swaminathan, M. (2013). Estimation of lipid peroxides and antioxidants in smokers and non-smokers with periodontitis. King Saud University Journal of Dental Sciences, 4, 53–6.
Rudrakshi, C., Prabhuji, M. L. V., Parween, S., & Jyothsna, S. (2017). Relationship between antioxidants and the development of the periodontal disease. J. Cytol. Tissue Biol, 4, 16.
Mokeem, S. A., Vellappally, S., Preethanath, R. S., Hashem, M. I., Al-Kheraif, A. A., & Anil, S. (2014). Influence of smoking on clinical parameters and gingival crevicular fluid volume in patients with chronic periodontitis. Oral health and dental management, 13, 469-73.
Şentürk, R.A., Sezgin, Y., Bulut, Ş. and Özdemir, B.H. (2018). The effects of smoking on the expression of gelatinases in chronic periodontitis: a cross-sectional study. Brazilian Oral Research, 32, e114.
Shirzaiy, M., Aiub Rigi Ladiz, M., Dalirsani, Z., Dehghan Haghighi, J. and Nakhaii, A. (2017). Evaluation of Salivary Total Antioxidant Capacity in Smokers with Severe Chronic Periodontitis. International Journal of High Risk Behaviors and Addiction, 6, e59486.
Sies, H. (2007). Total antioxidant capacity: appraisal of a concept. The Journal of Nutrition, 137, 1493–5.
Silness, J., & Löe, H. (1964). Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta odontologica scandinavica, 22, 121-35.
Hrishi, T. S., Menon, S. K., Kundapur, P., & Gupta, S. (2016). Comparative evaluation of GCF total antioxidant capacity in chronic periodontitis patients before and after non-surgical periodontal therapy. International Journal of Dental Research and Development, 6, 11-6.
Smiley, C.J., Tracy, S.L., Abt, E., Michalowicz, B.S., John, M.T., Gunsolley, J., Cobb, C.M., Rossmann, J., Harrel, S.K., Forrest, J.L., Hujoel, P.P., Noraian, K.W., Greenwell, H., Frantsve-Hawley, J., Estrich, C. and Hanson, N. (2015). Evidence-based clinical practice guideline on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. The Journal of the American Dental Association, 146, 525–35.
Söder, B., Nedlich, U. and Jin, L.J. (1999). Longitudinal Effect of Non-Surgical Treatment and Systemic Metronidazole for 1 Week in Smokers and Non-Smokers with Refractory Periodontitis: A 5-Year Study. Journal of Periodontology, 70, 761–71.
Sreedevi, M., Ramesh, A. and Dwarakanath, C. (2012). Periodontal Status in Smokers and Nonsmokers: A Clinical, Microbiological, and Histopathological Study. International Journal of Dentistry, 2012, 571-90.
Taba, M., Kinney, J., Kim, A.S. and Giannobile, W.V. (2005). Diagnostic biomarkers for oral and periodontal diseases. Dental Clinics of North America, 49, 551–571.
Talari, A. and Ainamo, J. (1976). Orthopantomographic assessment of the width of attached gingiva. Journal of Periodontal Research, 11, 177–81.
Taylor, G.W. and Borgnakke, W.S. (2008). Periodontal disease: associations with diabetes, glycemic control and complications. Oral Diseases, 14, 191–203.
Theodoro, L.H., Assem, N.Z., Longo, M., Alves, M.L.F., Duque, C., Stipp, R.N., Vizoto, N.L. and Garcia, V.G. (2018). Treatment of periodontitis in smokers with multiple sessions of antimicrobial photodynamic therapy or systemic antibiotics: A randomized clinical trial. Photodiagnosis and Photodynamic Therapy, 22, 217–22.
Thomas, B., Madani, S.M., Prasad, B.R. and Kumari, S. (2014). Comparative evaluation of serum antioxidant levels in periodontally diseased patients: An interventional study. Contemporary Clinical Dentistry, 5, 340–4.
Tsai, C.C., Chen, H.S., Chen, S.L., Ho, Y.P., Ho, K.Y., Wu, Y.M. and Hung, C.C. (2005). Lipid peroxidation: a possible role in the induction and progression of chronic periodontitis. Journal of Periodontal Research, 40, 378–84.
Visvanathan, R., Mahendra, J., N, A., Pandisuba and Chalini (2014). Effect of Smoking on Periodontal Health. Journal of Clinical and Diagnostic Research : JCDR, 8, 46–9.
Wei, D., Zhang, X.-L., Wang, Y.-Z., Yang, C.-X. and Chen, G. (2010). Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy. Australian Dental Journal, 55, 70–8.
Zhang, T., Andrukhov, O., Haririan, H., Müller-Kern, M., Liu, S., Liu, Z. and Rausch-Fan, X. (2016). Total Antioxidant Capacity and Total Oxidant Status in Saliva of Periodontitis Patients in Relation to Bacterial Load. Frontiers in Cellular and Infection Microbiology. Retrieved August 6, 2022, fromhttps://www.frontiersin.org/article/10.3389/fcimb.2015. 00097
Zhang, Y., He, J., He, B., Huang, R. and Li, M. (2019). Effect of tobacco on periodontal disease and oral cancer.Tobacco Induced Diseases, 17, 40.
Zhou, J., Olson, B.L. and Windsor, L.J. (2007). Nicotine increases the collagen-degrading ability of human gingival fibroblasts. Journal of Periodontal Research, 42, 228–35.
Published
2022-12-06
How to Cite
ALI, L. B., & MOHAMMAD, C. A. (2022). THE EFFECT OF NON-SURGICAL PERIODONTAL THERAPY ON PERIODONTAL PARAMETERS, MALONDIALDEHYDE, TOTAL OXIDANT STATUS AND ANTIOXIDANT CAPACITY IN SMOKERS WITH CHRONIC PERIODONTITIS. Journal of Duhok University, 25(2), 329-345. https://doi.org/10.26682/sjuod.2022.25.2.31
Section
Pure and Engineering Sciences
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