PROBIOTIC BACTERIAL EFFECTS ON THE TREATMENT OF CHRONIC PERIODONTITIS PATIENTS: A DOUBLE-BLIND STUDY

HARVEEN N.  ABDULLAH; SHERZAD KH.  RASHID

doi:10.26682/sjuod.2022.25.2.35

HARVEEN N. ABDULLAH Dept. of pharmacology and clinical pharmacy, College of pharmacy, University of Duhok, Kurdistan-Iraq
SHERZAD KH. RASHID Dept. of pharmacology and clinical pharmacy, College of pharmacy, University of Duhok, Kurdistan-Iraq

DOI: https://doi.org/10.26682/sjuod.2022.25.2.35

Keywords: Probiotics, GCF/MMP-8, GCF/IL-6, Chronic periodontitis, SRP

Abstract

Background: Technology of Probiotics indicates an approach discovery on sustaining oral health via helpful natural bacteria, which are usually found in the oral cavity, to make a good protection against those bacteria which are supposed to be destructive to gingival tissue and teeth.

Aims: This article goal was to assess the influence of probiotics that utilized as an adjunctive method to scaling and root planning (SRP) on measurements of the periodontium and matrix metalloproteinase-8 (MMP-8) and interleukin-6 (IL-6) levels in gingival crevicular fluid (GCF) of patients with chronic periodontitis.

Material and Methods: Forty persons aged between 35 and 55 years had chronic periodontitis were healthy systemically, and they had moderate to severe chronic periodontitis. Two groups of participants were created randomly double blindly. Both groups were assessed thirty days after beginning the periodontal treatment: the first group (N = 20) received SRP with a placebo, whereas the second group (N = 20) received SRP with probiotic capsules.

Results and Conclusion: The study results showed that periodontal indicators improved in both groups, particularly those with probiotic treatment. As well, they had a tendency for improvement but they were not statistically significant regarding the immunologic responses in those treated with probiotics as well as to SRP therapy than in patients treated with SRP alone

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