REASSESSMENT OF COAGULATION DYSFUNCTION AND ITS IMPACT ON CLASSIFICATION OF HEMOPHILIA IN DUHOK CITY

EMAN BUNYAN  IBRAHIM; RANA ADIL  HANOON

doi:10.26682/sjuod.2020.23.2.23

EMAN BUNYAN IBRAHIM Dept. of Biology, College of Science, University of Duhok, Kurdistan Region-Iraq
RANA ADIL HANOON Scientific Research Center, College of Science, University of Duhok, Kurdistan Region-Iraq

DOI: https://doi.org/10.26682/sjuod.2020.23.2.23

Keywords: factor VIII, factor IX, Duhok city, aPTT, types of hemophilia

Abstract

The X-linked inherited coagulation disorders, hemophilia A (Factor VIII deficiency) and hemophilia B (factor IXdeficiency) are the most prevalent coagulation dysfunction. The current study involved 75hemophlic patients who have been assigned into two groups; hemophilia A group consisted of 62 patients and hemophilia B group represented by 13 patients.

Venous blood of participants was withdrawn, routine coagulation (PT and aPTT) and specific clotting function test (FVIII, FIX, FXI and FXII) were investigated. PT and aPTT kit (BIOLAB^®, France) were used for the measurements of PT and aPTT times. STA^®-DEFICIENT VIII and IX reagent kit with Immuno-depleted plasma for FVIII and FIX assay were used for determination of FVIII and FIX activity, respectively. The procedure followed the manufacturer instructions of each particular test.The present study was investigated blood group in a hemophilic patient also .

The results revealed that hemophilia A patients exceeded the patients of hemophilia B and were represented by 82.7% and17.3% respectively. Furthermore, moderate cases of both types of hemophilia were greater than mild and severe cases. The results of this study indicated no significant correlation between the type of hemophilia from the one side and blood group and age from the other side. Conversely, significant correlation has been found between hemophilia and family history(P=0.001). The present study showed significant correlation between prolonged aPTT and hemophilia (P=0.00), while no-significant correlation has been found between prolonged PT and hemophilia. Finally, no significant correlation has been shown between age and the prolonged aPTT

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