EVALUATING THE INFLUENCE OF CURCUNIN ON BONE RESPONSE DURING TEETH DISPLACEMENT: AN EXPERMENTAL IN VIVO STUDY
Keywords:
Orthodontic treatment, Tooth movement acceleration, curcumin, histomorphometric analysis
Abstract
Background and objectives: Orthodontic treatment attempts to improve people's quality of life. A complex and lengthy inflammatory process including simultaneous bone resorption and apposition is required. The length of the treatment process is the most common complaint of patients seeking during treatment. The purpose of this experimental study is to determine the effects of three weeks consumption of curcumin on the rate of orthodontic tooth movement, the level of serum calcium- phosphorous and histomorphometric analysis.
Materials and methods: Twenty healthy male rabbits weighting 1.75 – 2 kg were used; the rabbits were divided in to two groups at random with each group consisting of ten rabbits. Both groups were subjected to orthodontic appliances with the study group receiving a daily dose of curcumin orally for 21 days.
Results: The study group showed tooth movement more than the control group with a decrease in the level of serum calcium and an increase in the level of serum phosphorous, the histomorphometric analysis showed an increase in the number of osteoblasts in the tension side and an increase in the number of osteoclasts in the compression side.
Conclusion: Consumption of curcumin improved the rate of orthodontic tooth movement
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References
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Sharma, S., & Ahuja, C. (2019). Ameliorating efficacy of curcumin on cadmium induced thyroid dysfunction in albino rats. Int. J. Sci. Res. in Biological Sciences Vol, 6, 1.
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Xie R, Kuijpers-Jagtman AM, Maltha JC, (2009). Osteoclast differentiation and recruitment during early stages of experimental tooth movement in rats. European Journal of Oral Science; 117: 43-50.
Xiong, Y., Zhao, B., Zhang, W., Jia, L., Zhang, Y., & Xu, X. (2020). Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway. Iranian Journal of Basic Medical Sciences, 23(7), 954
Abtahi, M., Saghravanian, N., Poosti, M., & Shafaee, H. (2018). Histological evaluation of orthodontic tooth movement following low-level laser irradiation in rabbits. Electronic physician, 10(1), 6219.
Alaraj, M., & Qiblawi, S. (2015). Protective effects of fish oil on carbon tetrachloride induced hepatotoxicity in rabbits. Int. J. Sci. Basic Appl. Res, 19, 400-408.
Al-Attar, A. M. (2020). Therapeutic influences of almond oil on male rats exposed to a sublethal concentration of lead. Saudi journal of biological sciences, 27(2), 581-587.
Al-Hamdany, A. K., Al-Khatib, A. R., & Al-Sadi, H. I. (2017). Influence of olive oil on alveolar bone response during orthodontic retention period: rabbit model study. Acta odontologica Scandinavica, 75(6), 413–422.
Al-Hasani, N. R., Al-Bustani, A. I., Ghareeb, M. M., & Hussain, S. A. (2011). Clinical efficacy of locally injected calcitriol in orthodontic tooth movement. Int J Pharm Pharm Sci, 3(5), 139-143.
Al-Khalifa, K. S., & Baeshen, H. A. (2020). Micro-osteoperforations and its effect on the rate of tooth movement: a systematic review. European Journal of Dentistry.
Al-Rubaei, Z. M., Mohammad, T. U., & Ali, L. K. (2014). Effects of local curcumin on oxidative stress and total antioxidant capacity in vivo study. Pak J Biol Sci, 17(12), 1237-1241.
Anwar, M., Shousha, W. G., El-mezayen, H. A., El-Wassef, M., Nazif, N. M., & El-bana, M. A. (2013). Antiatherogenic effect of almond oil in streptozotocin induced diabetic rats. Journal of Applied Pharmaceutical Science, 3(10), 59.
Arafath, M. (2012) the Effect of Bisphosphonate [Pamidronate] On Orthodontic Tooth Movement in Rabbits.
Caglaroglu M and Erdem A- (2012). Histopalhologic invesigsion of the elices
Craven R. (2007). Ketamine. Anaesthesia. 62 (1): 48-53.
Chen, S., Liang, H., Ji, Y., Kou, H., Zhang, C., Shang, G., ... & Liu, H. (2021). Curcumin modulates the crosstalk between macrophages and bone mesenchymal stem cells to ameliorate osteogenesis. Frontiers in Cell and Developmental Biology, 9, 634650.
Dai, P., Mao, Y., Sun, X., Li, X., Muhammad, I., Gu, W., & Huang, S. (2017). Attenuation of oxidative stress-induced osteoblast apoptosis by curcumin is associated with preservation of mitochondrial functions and increased Akt-GSK3β signaling. Cellular Physiology and Biochemistry, 41(2), 661-677.
Demir, O., & Arici, N. (2021). Dose-related effects of extracorporeal shock waves on orthodontic tooth movement in rabbits. Scientific Reports, 11(1), 1-11.
Huang, C. Y., Lu, H. P., Yu, Y. F., Ding, X., Zhang, Z. Z., & Zhang, J. N. (2021). Comparison of tooth movement and biological response resulting from different force magnitudes combined with osteoperforation in rabbits. Journal of Applied Oral Science, 29.
Joanne Sohn and Marcelo A (2012). Couto Chapter 8 in The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents, Pages 195-215.
Kilic N, Okay H and Ersöz M.(2010). Effects of force magnitude on tooth
Kim JY, Kim BI, Jue SS, Park JH, Shin JW, (2012). Localization of osteopontin
Madian, A. M., Abdallah, E. M., El Harouni, N. M., & Abdelmajeed, S. H. (2021). The Effect of Systemic Administration of Co-enzyme Q10 on Orthodontic Relapse in a rabbit model. Alexandria Dental Journal.
Mortensen, A., Hansen, B. F., Hansen, J. F., Frandsen, H., Bartnikowska, E., Andersen, P. S., & Bertelsen, L. S. (1998). Comparison of the effects of fish oil and olive oil on blood lipids and aortic atherosclerosis in Watanabe heritable hyperlipidaemic rabbits. British Journal of Nutrition, 80(6), 565-573.
Midgett, R. J., Shaye, R., & Fruge Jr, J. F. (1981). The effect of altered bone metabolism on orthodontic tooth movement. American journal of orthodontics, 80(3), 256-262.
Nakornnoi, T., Leethanakul, C., & Samruajbenjakun, B. (2019). The influence of leukocyte-platelet-rich plasma on accelerated orthodontic tooth movement in rabbits. The Korean Journal of Orthodontics, 49(6), 372-380.
National Institute of Health (2005). Anesthesia/Analgesia Formulary. Maryland, Office of Animal Care and Use. National Institutes of Health (NIH).
Pang, X. F., Zhang, L. H., Bai, F., Wang, N. P., Garner, R., & Zhao, Z. Q. (2014). Dual ACE-inhibition and angiotensin II AT1 receptor antagonism with curcumin attenuate maladaptive cardiac repair and improve ventricular systolic function after myocardial infarctionin rat heart. European Journal of Pharmacology, 746, 22-30.
Pizato, N., Luzete, B. C., Kiffer, L. F. M. V., Corrêa, L. H., de Oliveira Santos, I., Assumpção, J. A. F., ... & Magalhães, K. G. (2018). Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells. Scientific reports, 8(1), 1-12.
Pusi M. Basafa M, Eslami N.(2009) Progesterone effects on experimental
Ren Y, (2003). Age effect on orthodontic tooth movement. PhD thesis inMedical Science, Nijmegen University:3-4.
Ren Y, Maltha JC and Kuijpers-Jagtman AM, (2003). Optimum force magnitude to orthodontic tooth movement-a systematic review. Journal of Angle Orthodontic; 73: 86-92.
Ren Y, Maltha JC and Kuijpers-Jagtman AM, (2004).The rat as a model for orthodontic tooth movement-a critical review and a proposed solution. European Journal of Orthodontic;26: 483-490.
Sharma, S., & Ahuja, C. (2019). Ameliorating efficacy of curcumin on cadmium induced thyroid dysfunction in albino rats. Int. J. Sci. Res. in Biological Sciences Vol, 6, 1.
Suvarana SK, Layton C and Bancroft JD. (2013). Bancroft's Theory and Practice of Histological Techniques. Seventh Edition. Churchil Livingstone Elsevier. Pp: 317-48.
Vella D, et al.(2011). Feeding Recommendations for Pet Rabbits. Sydney Exotics +Rabbit Vets.
Wang, N., Wang, F., Gao, Y., Yin, P., Pan, C., Liu, W., & Wang, J. (2016). Curcumin protects human adipose-derived mesenchymal stem cells against oxidative stress-induced inhibition of osteogenesis. Journal of pharmacological sciences, 132(3), 192-200.
Xie R, Kuijpers-Jagtman AM, Maltha JC, (2009). Osteoclast differentiation and recruitment during early stages of experimental tooth movement in rats. European Journal of Oral Science; 117: 43-50.
Xiong, Y., Zhao, B., Zhang, W., Jia, L., Zhang, Y., & Xu, X. (2020). Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway. Iranian Journal of Basic Medical Sciences, 23(7), 954
Published
2023-05-18
How to Cite
NAWAF, R. M., & ALSULTAN, M. M. (2023). EVALUATING THE INFLUENCE OF CURCUNIN ON BONE RESPONSE DURING TEETH DISPLACEMENT: AN EXPERMENTAL IN VIVO STUDY. Journal of Duhok University, 26(1), 281-290. https://doi.org/10.26682/sjuod.2023.26.1.28
Section
Pure and Engineering Sciences
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