EFFECT OF OSTEONTM II COLLAGEN IN THE TREATMENT OF CHRONIC PERIODONTITIS PATIENTS: A CLINICAL AND RADIOGRAPHICAL STUDY
Keywords:
Bone graft, Chronic periodontitis, Osteon II collagen, Open flap debridement, Periodontal regeneration
Abstract
inflammatory disease that lasts for a long time and affects the soft and hard tissues around the teeth. The ultimate goal of periodontal therapy is to regenerate the lost periodontal tissue for optimal function and aesthetics. The aim of this study was to evaluate the clinical and radiographic effects of OsteonTM II collagen, in comparison with open flap debridement (OFD) in the treatment of chronic periodontitis patients.
Material and methods: 30 periodontal bony defects in 7 systemically healthy patients that had at least 3 defects, within the age range of 25–40 years, viewing moderate to severe chronic periodontitis were selected and randomly divided into two groups, control group(n=15) was treated by open flap debridement (OFD) alone and test group(n=15) was treated by OFD with placement of OsteonTM II Collagen. All the selected periodontal defects were evaluated with the clinical and radiographic parameters such as plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth. All the clinical and radiographic parameter values attained at (baseline and 6 months) were subjected to statistical analysis.
Results: Significant lessening in PI, GI, PPD, CAL and radiographic defect depth were detected after 6 months of periodontal surgery as compared to baseline in both groups (P<0.05). Superior decrease in PPD, gain in CAL and radiographic defect fill was seen in test group after 6 months.
Conclusion: In terms of reducing probing pocket depth (PPD), increasing clinical attachment level (CAL), and filling bone defects, OsteonTM II collagen showed significant clinical, radiographic, and statistical improvements compared to open flap debridement (OFD) alone
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References
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Chacko, N. L., Abraham, S., Rao, H. N., Sridhar, N., Moon, N., and Barde, D. H. (2014). A Clinical and Radiographic Evaluation of Periodontal Regenerative Potential of PerioGlas®: A Synthetic, Resorbable Material in Treating Periodontal Infrabony Defects. Journal of international oral health: JIOH, 6(3), 20–26.
Chandrashekar, K. T., & Saxena, C. (2009). Biograft-HT as a bone graft material in the treatment of periodontal vertical defects and its clinical and radiological evaluation: Clinical study. Journal of Indian Society of Periodontology, 13(3), 138–144.
Cho, Y. D., Kim, K. H., Lee, Y. M., Ku, Y., and Seol, Y. J. (2021). Periodontal Wound Healing and Tissue Regeneration: A Narrative Review. Pharmaceuticals (Basel, Switzerland), 14(5), 456.
Elbattawy, W., & Ahmed, D. (2021). Clinical and radiographic evaluation of open flap debridement with or without Nanocrystalline Hydroxyapatite bone graft in management of periodontal intrabony defects. Egyptian Dental Journal, 67(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 433-446.
Elkhatat, E. I., Elkhatat, A. E., Azzeghaiby, S. N., Tarakji, B., Beshr, K., and Mossa, H. (2015). Clinical and radiographic evaluation of periodontal intrabony defects by open flap surgery alone or in combination with Biocollagen(®) membrane: A randomized clinical trial. Journal of International Society of Preventive & Community Dentistry, 5(3), 190–198
Farha, L. S., and Abdulghani, M. M. (2017). Clinical and experimental study to evaluate the effect of biphasic calcium phosphate collagen composite (cpcc) on healing of bone defects after oral surgical procedures. Al-Kindy College Medical Journal, 13(2), 11-20.
Figliuzzi, M. M., Giudice, A., Pileggi, S., Scordamaglia, F., Marrelli, M., Tatullo, M., and Fortunato, L. (2016). Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis. Annali di stomatologia, 7(1-2), 16–23
Gojkov-Vukelic, M., Hadzic, S., and Pasic, E. (2017). Evaluation of Efficacy of Surgical Periodontal Therapy with the Use of Bone Graft in the Treatment of Periodontal Intrabony Defects. Medical archives (Sarajevo, Bosnia and Herzegovina), 71(3), 208–211.
Ihghaf, N. O. N., Tawfik, M. A. M., El–Hawary, Y. M., and Mansour, N. A. (2015). Osteon ii versus biogen in healing of jaw bone defects. Dental Journal, 61(4045), 4053.
Kamboj, M., Arora, R., and Gupta, H. (2016). Comparative evaluation of the efficacy of synthetic nanocrystalline hydroxyapatite bone graft (Ostim®) and synthetic microcrystalline hydroxyapatite bone graft (Osteogen®) in the treatment of human periodontal intrabony defects: A clinical and denta scan study. Journal of Indian Society of Periodontology, 20(4), 423–428.
Könönen, E., Gursoy, M., and Gursoy, U. K. (2019). Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues. Journal of clinical medicine, 8(8), 1135.
Ku, J. K., Hong, I., Lee, B. K., Yun, P. Y., and Lee, J. K. (2019). Dental alloplastic bone substitutes currently available in Korea. Journal of the Korean Association of Oral and Maxillofacial Surgeons, 45(2), 51–67.
Laurell, L., Gottlow, J., Zybutz, M., and Persson, R. (1998). Treatment of intrabony defects by different surgical procedures. A literature review. Journal of periodontology, 69(3), 303–313.
Lee, E. U., Kim, D. J., Lim, H. C., Lee, J. S., Jung, U. W., and Choi, S. H. (2015). Comparative evaluation of biphasic calcium phosphate and biphasic calcium phosphate collagen composite on osteoconductive potency in rabbit calvarial defect. Biomaterials research, 19, 1.
Lee, M. J., Kim, B. O., and Yu, S. J. (2012). Clinical evaluation of a biphasic calcium phosphate grafting material in the treatment of human periodontal intrabony defects. Journal of periodontal & implant science, 42(4), 127–135.
Liang, Y., Luan, X., and Liu, X. (2020). Recent advances in periodontal regeneration: A biomaterial perspective. Bioactive materials, 5(2), 297-308.
Mopur, J. M., Devi, T. R., Ali, S. M., Srinivasa, T. S., Gopinath, V., and Salam, A. R. (2013). Clinical and radiographic evaluation of regenerative potential of GTR membrane (Biomesh®) along with alloplastic bone graft (Biograft®) in the treatment of periodontal intrabony defects. The journal of contemporary dental practice, 14(3), 434–439.
Natto, Z. S., Abu Ahmad, R. H., Alsharif, L. T., Alrowithi, H. F., Alsini, D. A., Salih, H. A., and Bissada, N. F. (2018). Chronic Periodontitis Case Definitions and Confounders in Periodontal Research: A Systematic Assessment. BioMed research international, 2018, 4578782.
Pavani, M. P., Reddy, K. R. K. M., Reddy, B. H., Biraggari, S. K., Babu, C. H. C., and Chavan, V. (2021). Evaluation of platelet-rich fibrin and tricalcium phosphate bone graft in bone fill of intrabony defects using cone-beam computed tomography: A randomized clinical trial. Journal of Indian Society of Periodontology, 25(2), 138–143.
Rajamani, V. K., Udayshankar, V., Prakash, P., and Jain, V. (2019). Bone graft materials used in dental implants: A review. IP Annals of Prosthodontics and Restorative Dentistry, 5(3), 58-62.
Santosh Kumar, B. B., Aruna, D. R., Gowda, V. S., Galagali, S. R., Prashanthy, R., and Navaneetha, H. (2013). Clinical and radiographical evaluation of a bioresorbable collagen membrane of fish origin in the treatment of periodontal intrabony defects: A preliminary study. Journal of Indian Society of Periodontology, 17(5), 624–630.
Schmitt, S. M., and Brown, F. H. (1989). Management of root-amputated maxillary molar teeth: periodontal and prosthetic considerations. The Journal of prosthetic dentistry, 61(6), 648–652.
Silva, N., Abusleme, L., Bravo, D., Dutzan, N., Garcia-Sesnich, J., Vernal, R., Hernández, M., & Gamonal, J. (2015). Host response mechanisms in periodontal diseases. Journal of applied oral science: revista FOB, 23(3), 329–355.
Singh, V. P., Nayak, D. G., Uppoor, A. S., and Shah, D. (2012). Clinical and radiographic evaluation of Nano-crystalline hydroxyapatite bone graft (Sybograf) in combination with bioresorbable collagen membrane (Periocol) in periodontal intrabony defects. Dental research journal, 9(1), 60–67.
Stein, J. M., Fickl, S., Yekta, S. S., Hoischen, U., Ocklenburg, C., and Smeets, R. (2009). Clinical evaluation of a biphasic calcium composite grafting material in the treatment of human periodontal intrabony defects: a 12-month randomized controlled clinical trial. Journal of periodontology, 80(11), 1774–1782.
Suprabhan, S., Suchetha, A., Sapna, N., Darshan, B. M., Apoorva, S. M., and Bhat, D. (2020). A clinical and radiographic comparison of platelet-rich-fibrin and beta tri-calcium phosphate+ hydroxyapetite alloplastic bone graft (Osteon II®) in the treatment of periodontal intrabony defects. World Journal of Pharmaceutical Research, 9(7), 1723-1740.
Titsinides, S., Agrogiannis, G., and Karatzas, T. (2019). Bone grafting materials in dentoalveolar reconstruction: A comprehensive review. The Japanese dental science review, 55(1), 26–32.
Vaid, T., Kumar, S., Mehta, R., Shah, S., Joshi, S., Bhakkand, S., and Hirani, T. (2021). Clinical and radiographic evaluation of demineralized freeze-dried bone allograft with concentrated growth factor versus concentrated growth factor alone in the treatment of intrabony defects. Medicine and pharmacy reports, 94(2), 220–228.
Varghese, J., Rajagopal, A., and Shanmugasundaram, S. (2022). Role of biomaterials used for periodontal tissue regeneration—A concise evidence-based review. Polymers, 14(15), 3038
Abid, W. K., and Al Mukhtar, Y. H. (2019). Repair of surgical bone defects grafted with hydroxylapatite + β-TCP combined with hyaluronic acid and collagen membrane in rabbits: A histological study. Journal of Taibah University Medical Sciences, 14(1), 14–24.
Atchuta, A., Gooty, J. R., Guntakandla, V. R., Palakuru, S. K., Durvasula, S., and Palaparthy, R. (2020). Clinical and radiographic evaluation of platelet-rich fibrin as an adjunct to bone grafting demineralized freeze-dried bone allograft in intrabony defects. Journal of Indian Society of Periodontology, 24(1), 60–66.
Bae, J. H., Kim, Y. K., Kim, S. G., Yun, P. Y., and Kim, J. S. (2010). Sinus bone graft using new alloplastic bone graft material (Osteon)-II: clinical evaluation. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 109(3), e14–e20.
Bansal, R., Patil, S., Chaubey, K. K., Thakur, R. K., and Goyel, P. (2014). Clinical evaluation of hydroxyapatite and β-tricalcium phosphate composite graft in the treatment of intrabony periodontal defect: A clinico-radiographic study. Journal of Indian Society of Periodontology, 18(5), 610–617.
Chacko, N. L., Abraham, S., Rao, H. N., Sridhar, N., Moon, N., and Barde, D. H. (2014). A Clinical and Radiographic Evaluation of Periodontal Regenerative Potential of PerioGlas®: A Synthetic, Resorbable Material in Treating Periodontal Infrabony Defects. Journal of international oral health: JIOH, 6(3), 20–26.
Chandrashekar, K. T., & Saxena, C. (2009). Biograft-HT as a bone graft material in the treatment of periodontal vertical defects and its clinical and radiological evaluation: Clinical study. Journal of Indian Society of Periodontology, 13(3), 138–144.
Cho, Y. D., Kim, K. H., Lee, Y. M., Ku, Y., and Seol, Y. J. (2021). Periodontal Wound Healing and Tissue Regeneration: A Narrative Review. Pharmaceuticals (Basel, Switzerland), 14(5), 456.
Elbattawy, W., & Ahmed, D. (2021). Clinical and radiographic evaluation of open flap debridement with or without Nanocrystalline Hydroxyapatite bone graft in management of periodontal intrabony defects. Egyptian Dental Journal, 67(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 433-446.
Elkhatat, E. I., Elkhatat, A. E., Azzeghaiby, S. N., Tarakji, B., Beshr, K., and Mossa, H. (2015). Clinical and radiographic evaluation of periodontal intrabony defects by open flap surgery alone or in combination with Biocollagen(®) membrane: A randomized clinical trial. Journal of International Society of Preventive & Community Dentistry, 5(3), 190–198
Farha, L. S., and Abdulghani, M. M. (2017). Clinical and experimental study to evaluate the effect of biphasic calcium phosphate collagen composite (cpcc) on healing of bone defects after oral surgical procedures. Al-Kindy College Medical Journal, 13(2), 11-20.
Figliuzzi, M. M., Giudice, A., Pileggi, S., Scordamaglia, F., Marrelli, M., Tatullo, M., and Fortunato, L. (2016). Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis. Annali di stomatologia, 7(1-2), 16–23
Gojkov-Vukelic, M., Hadzic, S., and Pasic, E. (2017). Evaluation of Efficacy of Surgical Periodontal Therapy with the Use of Bone Graft in the Treatment of Periodontal Intrabony Defects. Medical archives (Sarajevo, Bosnia and Herzegovina), 71(3), 208–211.
Ihghaf, N. O. N., Tawfik, M. A. M., El–Hawary, Y. M., and Mansour, N. A. (2015). Osteon ii versus biogen in healing of jaw bone defects. Dental Journal, 61(4045), 4053.
Kamboj, M., Arora, R., and Gupta, H. (2016). Comparative evaluation of the efficacy of synthetic nanocrystalline hydroxyapatite bone graft (Ostim®) and synthetic microcrystalline hydroxyapatite bone graft (Osteogen®) in the treatment of human periodontal intrabony defects: A clinical and denta scan study. Journal of Indian Society of Periodontology, 20(4), 423–428.
Könönen, E., Gursoy, M., and Gursoy, U. K. (2019). Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues. Journal of clinical medicine, 8(8), 1135.
Ku, J. K., Hong, I., Lee, B. K., Yun, P. Y., and Lee, J. K. (2019). Dental alloplastic bone substitutes currently available in Korea. Journal of the Korean Association of Oral and Maxillofacial Surgeons, 45(2), 51–67.
Laurell, L., Gottlow, J., Zybutz, M., and Persson, R. (1998). Treatment of intrabony defects by different surgical procedures. A literature review. Journal of periodontology, 69(3), 303–313.
Lee, E. U., Kim, D. J., Lim, H. C., Lee, J. S., Jung, U. W., and Choi, S. H. (2015). Comparative evaluation of biphasic calcium phosphate and biphasic calcium phosphate collagen composite on osteoconductive potency in rabbit calvarial defect. Biomaterials research, 19, 1.
Lee, M. J., Kim, B. O., and Yu, S. J. (2012). Clinical evaluation of a biphasic calcium phosphate grafting material in the treatment of human periodontal intrabony defects. Journal of periodontal & implant science, 42(4), 127–135.
Liang, Y., Luan, X., and Liu, X. (2020). Recent advances in periodontal regeneration: A biomaterial perspective. Bioactive materials, 5(2), 297-308.
Mopur, J. M., Devi, T. R., Ali, S. M., Srinivasa, T. S., Gopinath, V., and Salam, A. R. (2013). Clinical and radiographic evaluation of regenerative potential of GTR membrane (Biomesh®) along with alloplastic bone graft (Biograft®) in the treatment of periodontal intrabony defects. The journal of contemporary dental practice, 14(3), 434–439.
Natto, Z. S., Abu Ahmad, R. H., Alsharif, L. T., Alrowithi, H. F., Alsini, D. A., Salih, H. A., and Bissada, N. F. (2018). Chronic Periodontitis Case Definitions and Confounders in Periodontal Research: A Systematic Assessment. BioMed research international, 2018, 4578782.
Pavani, M. P., Reddy, K. R. K. M., Reddy, B. H., Biraggari, S. K., Babu, C. H. C., and Chavan, V. (2021). Evaluation of platelet-rich fibrin and tricalcium phosphate bone graft in bone fill of intrabony defects using cone-beam computed tomography: A randomized clinical trial. Journal of Indian Society of Periodontology, 25(2), 138–143.
Rajamani, V. K., Udayshankar, V., Prakash, P., and Jain, V. (2019). Bone graft materials used in dental implants: A review. IP Annals of Prosthodontics and Restorative Dentistry, 5(3), 58-62.
Santosh Kumar, B. B., Aruna, D. R., Gowda, V. S., Galagali, S. R., Prashanthy, R., and Navaneetha, H. (2013). Clinical and radiographical evaluation of a bioresorbable collagen membrane of fish origin in the treatment of periodontal intrabony defects: A preliminary study. Journal of Indian Society of Periodontology, 17(5), 624–630.
Schmitt, S. M., and Brown, F. H. (1989). Management of root-amputated maxillary molar teeth: periodontal and prosthetic considerations. The Journal of prosthetic dentistry, 61(6), 648–652.
Silva, N., Abusleme, L., Bravo, D., Dutzan, N., Garcia-Sesnich, J., Vernal, R., Hernández, M., & Gamonal, J. (2015). Host response mechanisms in periodontal diseases. Journal of applied oral science: revista FOB, 23(3), 329–355.
Singh, V. P., Nayak, D. G., Uppoor, A. S., and Shah, D. (2012). Clinical and radiographic evaluation of Nano-crystalline hydroxyapatite bone graft (Sybograf) in combination with bioresorbable collagen membrane (Periocol) in periodontal intrabony defects. Dental research journal, 9(1), 60–67.
Stein, J. M., Fickl, S., Yekta, S. S., Hoischen, U., Ocklenburg, C., and Smeets, R. (2009). Clinical evaluation of a biphasic calcium composite grafting material in the treatment of human periodontal intrabony defects: a 12-month randomized controlled clinical trial. Journal of periodontology, 80(11), 1774–1782.
Suprabhan, S., Suchetha, A., Sapna, N., Darshan, B. M., Apoorva, S. M., and Bhat, D. (2020). A clinical and radiographic comparison of platelet-rich-fibrin and beta tri-calcium phosphate+ hydroxyapetite alloplastic bone graft (Osteon II®) in the treatment of periodontal intrabony defects. World Journal of Pharmaceutical Research, 9(7), 1723-1740.
Titsinides, S., Agrogiannis, G., and Karatzas, T. (2019). Bone grafting materials in dentoalveolar reconstruction: A comprehensive review. The Japanese dental science review, 55(1), 26–32.
Vaid, T., Kumar, S., Mehta, R., Shah, S., Joshi, S., Bhakkand, S., and Hirani, T. (2021). Clinical and radiographic evaluation of demineralized freeze-dried bone allograft with concentrated growth factor versus concentrated growth factor alone in the treatment of intrabony defects. Medicine and pharmacy reports, 94(2), 220–228.
Varghese, J., Rajagopal, A., and Shanmugasundaram, S. (2022). Role of biomaterials used for periodontal tissue regeneration—A concise evidence-based review. Polymers, 14(15), 3038
Published
2023-05-21
How to Cite
GRO , R. H., & MOUSA, H. D. (2023). EFFECT OF OSTEONTM II COLLAGEN IN THE TREATMENT OF CHRONIC PERIODONTITIS PATIENTS: A CLINICAL AND RADIOGRAPHICAL STUDY. Journal of Duhok University, 26(1), 336-347. https://doi.org/10.26682/sjuod.2023.26.1.32
Section
Pure and Engineering Sciences
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