THE IMPACT OF NATURAL PRODUCTS EXTRACTS ON ORTHODONTIC TEETH MOVEMENT: AN EXPERIMENTAL IN VIVO STUDY
Keywords:
Orthodontic teeth movements, Virgin coconut oil, Green tea, Pomegranate
Abstract
Background: The use of natural products in the field of dental health and improving oral hygiene is well established in multiple previous studies. However, their use in orthodontics and especially their impacts on teeth movements have not been previously described. Among the wide range of natural products spread in many parts of the world and the increased interest in them in recent years are green tea, pomegranate extracts and virgin coconut oil.
Aims: This experimental study aimed to estimate the impact of green tea extract, pomegranate extract and virgin coconut oil on orthodontic teeth movement.
Methods: An experimental in vivo study design was adopted to conduct this study. Forty rabbits were selected for the experiments. Inclusion criteria were rabbits to be of good health, without dental abnormalities, weight of 1.7-2 kilogram (average adult rabbit weight), aged 7-10 months. Exclusion criteria were rabbits outside the aforementioned parameters, and those who have dental abnormalities. Four groups were assigned with 10 rabbits in each. One group was control, and other three groups were green tea, virgin coconut oil, and pomegranate. Selected rabbits underwent orthodontic experiment , and the study groups started feeding on these three natural products. After three weeks study period, distance obtained from tooth movement and serum calcium and phosphorus were measured.
Results: Statistical analysis comparing the means of these studied groups revealed a statistically significant differences in the orthodontic teeth distance obtained by the coconut oil group versus the other studied groups (p = 0.03). Additionally, A student t-test analysis to compare means of serum calcium and phosphorus levels showed no statistically significant differences between the mean differences in serum calcium levels (p = 0.84) and mean serum phosphorus levels (p = 0.56).
Conclusion: Rabbits received virgin coconut oil feeding protocol obtained higher mean orthodontic teeth movement distance compared to control, green tea, and pomegranate groups
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References
H. F. Ji, X. J. Li, and H. Y. Zhang, “Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?,” EMBO Rep., vol. 10, no. 3, p. 194, 2009, doi: 10.1038/EMBOR.2009.12.
A. Kacprzak and A. Strzecki, “Methods of accelerating orthodontic tooth movement: A review of contemporary literature,” Dent. Med. Probl., vol. 55, no. 2, pp. 197–206, Apr. 2018, doi: 10.17219/DMP/90989.
D. J. Sinha and A. A. Sinha, “Natural medicaments in dentistry,” Ayu, vol. 35, no. 2, p. 113, 2014, doi: 10.4103/0974-8520.146198.
H. Sakagami and M. Tomomura, “Dental Application of Natural Products,” Medicines, vol. 5, no. 1, p. 21, Feb. 2018, doi: 10.3390/MEDICINES5010021.
G. Sridevi, S. Srividya, G. Sridevi, and S. Srividya, “Novel Dental Implants with Herbal Composites: A Review,” Mar. 2022, doi: 10.5772/INTECHOPEN.101489.
Z. Hayatullina, N. Muhammad, N. Mohamed, and I. N. Soelaiman, “Virgin coconut oil supplementation prevents bone loss in osteoporosis rat model,” Evidence-based Complement. Altern. Med., vol. 2012, 2012, doi: 10.1155/2012/237236.
M. Spilmont et al., “Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis,” Eur. J. Nutr., vol. 53, no. 5, pp. 1155–1164, 2014, doi: 10.1007/S00394-013-0615-6.
W. Xue, J. Yu, and W. Chen, “Plants and Their Bioactive Constituents in Mesenchymal Stem Cell-Based Periodontal Regeneration: A Novel Prospective,” Biomed Res. Int., vol. 2018, 2018, doi: 10.1155/2018/7571363.
K. Gulabivala and F. B. Naini, “The ortho-endo interface,” Endod. Fourth Ed., pp. 329–333, Jan. 2014, doi: 10.1016/B978-0-7020-3155-7.00013-8.
M. A. Asiry, “Biological aspects of orthodontic tooth movement: A review of literature,” Saudi J. Biol. Sci., vol. 25, no. 6, p. 1027, Sep. 2018, doi: 10.1016/J.SJBS.2018.03.008.
H. T. Huang et al., “Osteoprotective Roles of Green Tea Catechins,” Antioxidants 2020, Vol. 9, Page 1136, vol. 9, no. 11, p. 1136, Nov. 2020, doi: 10.3390/ANTIOX9111136.
Y. Li, L. A. Jacox, S. H. Little, and C. C. Ko, “Orthodontic tooth movement: The biology and clinical implications,” Kaohsiung J. Med. Sci., vol. 34, no. 4, pp. 207–214, Apr. 2018, doi: 10.1016/J.KJMS.2018.01.007.
C. Liu, P. Sharpe, and A. A. Volponi, “Applications of regenerative techniques in adult orthodontics,” Front. Dent. Med., vol. 3, p. 86, Jan. 2023, doi: 10.3389/FDMED.2022.1100548.
C. C. Martíınez, M. D. Gómez, and M. S. Oh, “Use of traditional herbal medicine as an alternative in dental treatment in Mexican dentistry: a review,” Pharm. Biol., vol. 55, no. 1, p. 1992, 2017, doi: 10.1080/13880209.2017.1347188.
H. A. Wahab, R. A. Eldamhogy, N. S. El-Moukhdem, and M. Abdel-Gabbar, “The Protective Role of Green Tea Against Ethanol-mediated Bone Alterations in Adult Male Rabbits: Biochemical, Histological and Morphometrical Study,” Egypt. J. Histol., vol. 44, no. 1, pp. 206–217, Mar. 2021, doi: 10.21608/EJH.2020.24761.1254.
M. M. H. Al-Sultan and A. R. Al-Khatib, “Natural products extract effect on bone integration around orthodontic micro-implant: An experimental study,” Zanco J. Med. Sci. (Zanco J Med Sci), vol. 20, no. 1, pp. 1219_1227-1219_1227, Apr. 2016, doi: 10.15218/ZJMS.2016.0012.
M. Spilmont et al., “Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis,” Eur. J. Nutr., vol. 53, no. 5, pp. 1155–1164, 2014, doi: 10.1007/S00394-013-0615-6.
A. M. Mudhir, R. M. Al-Maroof, and F. Y. Jasim, “Effects of infliximab local injection on orthodontic tooth movement in diabetic rabbits: A histological study,” Zanco J. Med. Sci. (Zanco J Med Sci), vol. 20, no. 2, pp. 1337–1348, Aug. 2016, doi: 10.15218/ZJMS.2016.0029.
H. Shiyan, R. Nanquan, X. Shuhao, and L. Xiaobing, “[Research progress on the cellular and molecular mechanisms of tooth eruption],” Hua Xi Kou Qiang Yi Xue Za Zhi, vol. 34, no. 3, pp. 317–321, Jun. 2016, doi: 10.7518/HXKQ.2016.03.020.
P. Jain and M. Rathee, “Anatomy, Head and Neck, Tooth Eruption,” StatPearls, Jun. 2022, Accessed: Feb. 28, 2023. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK549878/.
B. Sarrafpour, M. Swain, Q. Li, and H. Zoellner, “Tooth Eruption Results from Bone Remodelling Driven by Bite Forces Sensed by Soft Tissue Dental Follicles: A Finite Element Analysis,” PLoS One, vol. 8, no. 3, p. e58803, Mar. 2013, doi: 10.1371/JOURNAL.PONE.0058803.
A. A. Rabea, “Recent advances in understanding theories of eruption (evidence based review article),” Futur. Dent. J., vol. 4, no. 2, pp. 189–196, Dec. 2018, doi: 10.1016/J.FDJ.2018.05.001.
B. I. Aslan, N. Üçüncü, B. I. Aslan, and N. Üçüncü, “Clinical Consideration and Management of Impacted Maxillary Canine Teeth,” Emerg. Trends Oral Heal. Sci. Dent., Mar. 2015, doi: 10.5772/59324.
I. Kjaer, “Mechanism of Human Tooth Eruption: Review Article Including a New Theory for Future Studies on the Eruption Process,” Scientifica (Cairo)., vol. 2014, no. 3, pp. 189–209, 2014, doi: 10.1155/2014/341905.
H. Khorshidi, M. Moaddeli, A. Golkari, H. Heidari, and S. Raoofi, “The prevalence of pathologic tooth migration with respect to the severity of periodontitis,” J. Int. Soc. Prev. Community Dent., vol. 6, no. Suppl 2, p. S122, Aug. 2016, doi: 10.4103/2231-0762.189738.
H. Dadlani, S. S. Ramachandra, and D. S. Mehta, “Spontaneous correction of pathologically migrated teeth with periodontal therapy alone,” J. Indian Soc. Periodontol., vol. 17, no. 4, p. 531, Jul. 2013, doi: 10.4103/0972-124X.118331.
H. Işeri, G. Kurt, and R. Kişnişci, “Biomechanics of Rapid Tooth Movement by Dentoalveolar Distraction Osteogenesis,” Curr. Ther. Orthod., pp. 321–337, 2010, doi: 10.1016/B978-0-323-05460-7.00025-9.
“WHO Global Centre for Traditional Medicine .” https://www.who.int/initiatives/who-global-centre-for-traditional-medicine (accessed Feb. 28, 2023).
J. Kusnoto, H. Halim, B. Oetomo Roeslan, and C. Author, “Chewing Gum, Acetaminophen, and Green Tea Effect in Reducing Pain After Orthodontic Appliance Placement,” Sci. Dent. J., vol. 2, no. 2, pp. 51–57, May 2018, doi: 10.26912/SDJ.V2I2.2530.
“East Java green tea methanolic extract can enhance RUNX2 and Osterix expression during orthodontic tooth movement in vivo | Journal of Pharmacy & Pharmacognosy Research: The Blog.” https://jppres.wordpress.com/2020/04/09/east-java-green-tea-methanolic-extract-can-enhance-runx2-and-osterix-expression-during-orthodontic-tooth-movement-in-vivo/ (accessed Mar. 01, 2023).
S. Liao et al., “Application of green tea extracts epigallocatechin-3-gallate in dental materials: Recent progress and perspectives,” J. Biomed. Mater. Res. Part A, vol. 108, no. 12, pp. 2395–2408, Dec. 2020, doi: 10.1002/JBM.A.36991.
F. Ripari, F. Filippone, G. Zumbo, F. Covello, F. Zara, and I. Vozza, “The Role of Coconut Oil in Treating Patients Affected by Plaque-Induced Gingivitis: A Pilot Study,” Eur. J. Dent., vol. 14, no. 4, p. 558, Oct. 2020, doi: 10.1055/S-0040-1714194.
D. S. Kote, D. S. Kote, and D. L. Nagesh, “Effect of Pomegranate Juice on Dental Plaque Microorganisms (Streptococci and Lactobacilli),” Anc. Sci. Life, vol. 31, no. 2, p. 49, Oct. 2011, Accessed: Mar. 01, 2023. [Online]. Available: /pmc/articles/PMC3530267/.
G. L. Fernandes et al., “Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate,” Antibiotics, vol. 11, no. 11, p. 1477, Nov. 2022, doi: 10.3390/ANTIBIOTICS11111477/S1.
“Evaluation of efficacy of virgin coconut oil in maintaining hygiene in orthodontics patients.” https://www.cabdirect.org/globalhealth/abstract/20203296480 (accessed Mar. 01, 2023).
J. Woolley, T. Gibbons, K. Patel, and R. Sacco, “The effect of oil pulling with coconut oil to improve dental hygiene and oral health: A systematic review,” Heliyon, vol. 6, no. 8, p. e04789, Aug. 2020, doi: 10.1016/J.HELIYON.2020.E04789.
Thahir, H., Irawaty Djais, A., Nasir, M., Rahayu Feblina, A., Annisa, A., Etriyani, N., & Achmad, H. (2022). Virgin Coconut Oil as a New Concept for Periodontal Tissue Regeneration via Expressions of TNF-α and TGF-β1. International journal of biomaterials, 2022, 7562608. https://doi.org/10.1155/2022/7562608.
Belenguer, G., Duart-Abadia, P., Jordán-Pla, A., Domingo-Muelas, A., Blasco-Chamarro, L., Ferrón, S. R., Morante-Redolat, J. M., & Fariñas, I. (2021). Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling. Cell stem cell, 28(2), 285–299.e9. https://doi.org/10.1016/j.stem.2020.10.016.
Nakao, Y., Fukuda, T., Zhang, Q., Sanui, T., Shinjo, T., Kou, X., Chen, C., Liu, D., Watanabe, Y., Hayashi, C., Yamato, H., Yotsumoto, K., Tanaka, U., Taketomi, T., Uchiumi, T., Le, A. D., Shi, S., & Nishimura, F. (2021). Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. Acta biomaterialia, 122, 306–324. https://doi.org/10.1016/j.actbio.2020.12.046.
Pan, W., Wang, Q., & Chen, Q. (2019). The cytokine network involved in the host immune response to periodontitis. International journal of oral science, 11(3), 30. https://doi.org/10.1038/s41368-019-0064-z.
A. Kacprzak and A. Strzecki, “Methods of accelerating orthodontic tooth movement: A review of contemporary literature,” Dent. Med. Probl., vol. 55, no. 2, pp. 197–206, Apr. 2018, doi: 10.17219/DMP/90989.
D. J. Sinha and A. A. Sinha, “Natural medicaments in dentistry,” Ayu, vol. 35, no. 2, p. 113, 2014, doi: 10.4103/0974-8520.146198.
H. Sakagami and M. Tomomura, “Dental Application of Natural Products,” Medicines, vol. 5, no. 1, p. 21, Feb. 2018, doi: 10.3390/MEDICINES5010021.
G. Sridevi, S. Srividya, G. Sridevi, and S. Srividya, “Novel Dental Implants with Herbal Composites: A Review,” Mar. 2022, doi: 10.5772/INTECHOPEN.101489.
Z. Hayatullina, N. Muhammad, N. Mohamed, and I. N. Soelaiman, “Virgin coconut oil supplementation prevents bone loss in osteoporosis rat model,” Evidence-based Complement. Altern. Med., vol. 2012, 2012, doi: 10.1155/2012/237236.
M. Spilmont et al., “Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis,” Eur. J. Nutr., vol. 53, no. 5, pp. 1155–1164, 2014, doi: 10.1007/S00394-013-0615-6.
W. Xue, J. Yu, and W. Chen, “Plants and Their Bioactive Constituents in Mesenchymal Stem Cell-Based Periodontal Regeneration: A Novel Prospective,” Biomed Res. Int., vol. 2018, 2018, doi: 10.1155/2018/7571363.
K. Gulabivala and F. B. Naini, “The ortho-endo interface,” Endod. Fourth Ed., pp. 329–333, Jan. 2014, doi: 10.1016/B978-0-7020-3155-7.00013-8.
M. A. Asiry, “Biological aspects of orthodontic tooth movement: A review of literature,” Saudi J. Biol. Sci., vol. 25, no. 6, p. 1027, Sep. 2018, doi: 10.1016/J.SJBS.2018.03.008.
H. T. Huang et al., “Osteoprotective Roles of Green Tea Catechins,” Antioxidants 2020, Vol. 9, Page 1136, vol. 9, no. 11, p. 1136, Nov. 2020, doi: 10.3390/ANTIOX9111136.
Y. Li, L. A. Jacox, S. H. Little, and C. C. Ko, “Orthodontic tooth movement: The biology and clinical implications,” Kaohsiung J. Med. Sci., vol. 34, no. 4, pp. 207–214, Apr. 2018, doi: 10.1016/J.KJMS.2018.01.007.
C. Liu, P. Sharpe, and A. A. Volponi, “Applications of regenerative techniques in adult orthodontics,” Front. Dent. Med., vol. 3, p. 86, Jan. 2023, doi: 10.3389/FDMED.2022.1100548.
C. C. Martíınez, M. D. Gómez, and M. S. Oh, “Use of traditional herbal medicine as an alternative in dental treatment in Mexican dentistry: a review,” Pharm. Biol., vol. 55, no. 1, p. 1992, 2017, doi: 10.1080/13880209.2017.1347188.
H. A. Wahab, R. A. Eldamhogy, N. S. El-Moukhdem, and M. Abdel-Gabbar, “The Protective Role of Green Tea Against Ethanol-mediated Bone Alterations in Adult Male Rabbits: Biochemical, Histological and Morphometrical Study,” Egypt. J. Histol., vol. 44, no. 1, pp. 206–217, Mar. 2021, doi: 10.21608/EJH.2020.24761.1254.
M. M. H. Al-Sultan and A. R. Al-Khatib, “Natural products extract effect on bone integration around orthodontic micro-implant: An experimental study,” Zanco J. Med. Sci. (Zanco J Med Sci), vol. 20, no. 1, pp. 1219_1227-1219_1227, Apr. 2016, doi: 10.15218/ZJMS.2016.0012.
M. Spilmont et al., “Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis,” Eur. J. Nutr., vol. 53, no. 5, pp. 1155–1164, 2014, doi: 10.1007/S00394-013-0615-6.
A. M. Mudhir, R. M. Al-Maroof, and F. Y. Jasim, “Effects of infliximab local injection on orthodontic tooth movement in diabetic rabbits: A histological study,” Zanco J. Med. Sci. (Zanco J Med Sci), vol. 20, no. 2, pp. 1337–1348, Aug. 2016, doi: 10.15218/ZJMS.2016.0029.
H. Shiyan, R. Nanquan, X. Shuhao, and L. Xiaobing, “[Research progress on the cellular and molecular mechanisms of tooth eruption],” Hua Xi Kou Qiang Yi Xue Za Zhi, vol. 34, no. 3, pp. 317–321, Jun. 2016, doi: 10.7518/HXKQ.2016.03.020.
P. Jain and M. Rathee, “Anatomy, Head and Neck, Tooth Eruption,” StatPearls, Jun. 2022, Accessed: Feb. 28, 2023. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK549878/.
B. Sarrafpour, M. Swain, Q. Li, and H. Zoellner, “Tooth Eruption Results from Bone Remodelling Driven by Bite Forces Sensed by Soft Tissue Dental Follicles: A Finite Element Analysis,” PLoS One, vol. 8, no. 3, p. e58803, Mar. 2013, doi: 10.1371/JOURNAL.PONE.0058803.
A. A. Rabea, “Recent advances in understanding theories of eruption (evidence based review article),” Futur. Dent. J., vol. 4, no. 2, pp. 189–196, Dec. 2018, doi: 10.1016/J.FDJ.2018.05.001.
B. I. Aslan, N. Üçüncü, B. I. Aslan, and N. Üçüncü, “Clinical Consideration and Management of Impacted Maxillary Canine Teeth,” Emerg. Trends Oral Heal. Sci. Dent., Mar. 2015, doi: 10.5772/59324.
I. Kjaer, “Mechanism of Human Tooth Eruption: Review Article Including a New Theory for Future Studies on the Eruption Process,” Scientifica (Cairo)., vol. 2014, no. 3, pp. 189–209, 2014, doi: 10.1155/2014/341905.
H. Khorshidi, M. Moaddeli, A. Golkari, H. Heidari, and S. Raoofi, “The prevalence of pathologic tooth migration with respect to the severity of periodontitis,” J. Int. Soc. Prev. Community Dent., vol. 6, no. Suppl 2, p. S122, Aug. 2016, doi: 10.4103/2231-0762.189738.
H. Dadlani, S. S. Ramachandra, and D. S. Mehta, “Spontaneous correction of pathologically migrated teeth with periodontal therapy alone,” J. Indian Soc. Periodontol., vol. 17, no. 4, p. 531, Jul. 2013, doi: 10.4103/0972-124X.118331.
H. Işeri, G. Kurt, and R. Kişnişci, “Biomechanics of Rapid Tooth Movement by Dentoalveolar Distraction Osteogenesis,” Curr. Ther. Orthod., pp. 321–337, 2010, doi: 10.1016/B978-0-323-05460-7.00025-9.
“WHO Global Centre for Traditional Medicine .” https://www.who.int/initiatives/who-global-centre-for-traditional-medicine (accessed Feb. 28, 2023).
J. Kusnoto, H. Halim, B. Oetomo Roeslan, and C. Author, “Chewing Gum, Acetaminophen, and Green Tea Effect in Reducing Pain After Orthodontic Appliance Placement,” Sci. Dent. J., vol. 2, no. 2, pp. 51–57, May 2018, doi: 10.26912/SDJ.V2I2.2530.
“East Java green tea methanolic extract can enhance RUNX2 and Osterix expression during orthodontic tooth movement in vivo | Journal of Pharmacy & Pharmacognosy Research: The Blog.” https://jppres.wordpress.com/2020/04/09/east-java-green-tea-methanolic-extract-can-enhance-runx2-and-osterix-expression-during-orthodontic-tooth-movement-in-vivo/ (accessed Mar. 01, 2023).
S. Liao et al., “Application of green tea extracts epigallocatechin-3-gallate in dental materials: Recent progress and perspectives,” J. Biomed. Mater. Res. Part A, vol. 108, no. 12, pp. 2395–2408, Dec. 2020, doi: 10.1002/JBM.A.36991.
F. Ripari, F. Filippone, G. Zumbo, F. Covello, F. Zara, and I. Vozza, “The Role of Coconut Oil in Treating Patients Affected by Plaque-Induced Gingivitis: A Pilot Study,” Eur. J. Dent., vol. 14, no. 4, p. 558, Oct. 2020, doi: 10.1055/S-0040-1714194.
D. S. Kote, D. S. Kote, and D. L. Nagesh, “Effect of Pomegranate Juice on Dental Plaque Microorganisms (Streptococci and Lactobacilli),” Anc. Sci. Life, vol. 31, no. 2, p. 49, Oct. 2011, Accessed: Mar. 01, 2023. [Online]. Available: /pmc/articles/PMC3530267/.
G. L. Fernandes et al., “Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate,” Antibiotics, vol. 11, no. 11, p. 1477, Nov. 2022, doi: 10.3390/ANTIBIOTICS11111477/S1.
“Evaluation of efficacy of virgin coconut oil in maintaining hygiene in orthodontics patients.” https://www.cabdirect.org/globalhealth/abstract/20203296480 (accessed Mar. 01, 2023).
J. Woolley, T. Gibbons, K. Patel, and R. Sacco, “The effect of oil pulling with coconut oil to improve dental hygiene and oral health: A systematic review,” Heliyon, vol. 6, no. 8, p. e04789, Aug. 2020, doi: 10.1016/J.HELIYON.2020.E04789.
Thahir, H., Irawaty Djais, A., Nasir, M., Rahayu Feblina, A., Annisa, A., Etriyani, N., & Achmad, H. (2022). Virgin Coconut Oil as a New Concept for Periodontal Tissue Regeneration via Expressions of TNF-α and TGF-β1. International journal of biomaterials, 2022, 7562608. https://doi.org/10.1155/2022/7562608.
Belenguer, G., Duart-Abadia, P., Jordán-Pla, A., Domingo-Muelas, A., Blasco-Chamarro, L., Ferrón, S. R., Morante-Redolat, J. M., & Fariñas, I. (2021). Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling. Cell stem cell, 28(2), 285–299.e9. https://doi.org/10.1016/j.stem.2020.10.016.
Nakao, Y., Fukuda, T., Zhang, Q., Sanui, T., Shinjo, T., Kou, X., Chen, C., Liu, D., Watanabe, Y., Hayashi, C., Yamato, H., Yotsumoto, K., Tanaka, U., Taketomi, T., Uchiumi, T., Le, A. D., Shi, S., & Nishimura, F. (2021). Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. Acta biomaterialia, 122, 306–324. https://doi.org/10.1016/j.actbio.2020.12.046.
Pan, W., Wang, Q., & Chen, Q. (2019). The cytokine network involved in the host immune response to periodontitis. International journal of oral science, 11(3), 30. https://doi.org/10.1038/s41368-019-0064-z.
Published
2023-09-20
How to Cite
ABBOOD, A. K., & AL-SULTAN, M. M. H. (2023). THE IMPACT OF NATURAL PRODUCTS EXTRACTS ON ORTHODONTIC TEETH MOVEMENT: AN EXPERIMENTAL IN VIVO STUDY. Journal of Duhok University, 26(2), 57-66. https://doi.org/10.26682/sjuod.2023.26.2.7
Section
Pure and Engineering Sciences
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