EFFECT OF VITAMIN D3 AND K2 AS ADJUNCT TO  PERIODONTAL THERAPY

NAREEN RAFEEQ   MOHAMMED; HASHIM DAWOOD  MOUSA

doi:10.26682/sjuod.2023.26.2.14

NAREEN RAFEEQ MOHAMMED Dept. of Periodontics, College of Dentistry, University of Duhok, Kurdistan Region-Iraq
HASHIM DAWOOD MOUSA Dept. of Periodontics, College of Dentistry, University of Duhok, Kurdistan Region-Iraq

DOI: https://doi.org/10.26682/sjuod.2023.26.2.14

Keywords: Vit D3, Chronic periodontitis, Vit K2

Abstract

Background and Objectives: chronic periodontitis is a prevalent disease among the adult population that can cause serious damage to the periodontal tissue. Vitamin D3 deficiency/insufficiency is a global public health issue that has been linked to various inflammatory disorders, including periodontitis. Vitamin K2 has recently gained importance as a potential therapeutic agent because it regulates body calcium metabolism. The use of Vitamin D3 and K2 supplementation as adjunctive during non-surgical periodontal treatment (NSPT) can help improve the treatment outcome and the severity of chronic periodontitis. Further research is needed to determine the optimal dosage and duration of supplementation required for maximum benefit.

Material and methods: involved 45 systemically healthy patients between the ages of range 20-45 years viewing moderate to severe chronic periodontitis were selected and randomly divided into 3 groups, the control group (n= 15) received conventional periodontal treatment, Drug and SRP group (n=15) received conventional periodontal treatment with pharmaceutical intervention (Vit D3 5000 iu + K2 100mg ) for the treatment of vitamin D deficiency and Drug group (n=15) received the pharmaceutical intervention (Vit D3 5000 iu +K2 100mg) for the treatment of vitamin D deficiency.

Result: Significant reductions in PI, GI, and CAL were detected after 2 months of non-surgical periodontal treatment (NSPT) with Vitamin D3 and K2 supplementation compared to baseline in both groups (Drug+ SRP and Drug group). Superior decrease than the control group.

Conclusion: Taking vitamin D3 and K2 supplements along with non-surgical periodontal treatment could be a good option for treatment in the future

Downloads

Download data is not yet available.

References

Alzahrani A, Alharbi R, Alzahrani M, Sindi M, Shamlan G, Alzahrani F, Albanghali M, Sindi A, (2021). Association between periodontitis and vitamin D status: A case-control study. Saudi J. Biol. Sci; 28:4016–4021.
Botelho J, Machado V, Proenca L, Delgado AS, Mendes JJ, (2020). Vitamin D deficiency and oral health: a comprehensive review. Nutrients; 12(5):1471.
Butera A, Maiorani C, Gallo S, Pascadopoli M, Venugopal A, Marya A, Scribante A, (2022). Evaluation of Adjuvant Systems in Non-Surgical Peri-Implant Treatment: A Literature Review. Healthcare;10, 886.
Caton J.G, Armitage G, Berglundh T, Chapple I.L.C, Jepsen S, Kornman K.S, Mealey B.L, Papapanou P.N, Sanz M, Tonetti M.S, (2018). A new classification scheme for periodontal and peri-implant diseases and conditions–Introduction and key changes from the 1999 classification. J. Periodontol; 45:1–8.
Dragonas P, El-Sioufi I, Bobetsis YA, Madianos PN, (2020). Association of vitamin D with periodontal disease: a narrative review. Oral Health Prev Dent; 18(2):103–14.
Ebersole J.L, Lambert J, Bush. H, Huja P.E, Basu A, (2018). Serum Nutrient Levels and Aging Effects on Periodontitis. Nutrients; 10, 1986.
Gao W, Tang H, Wang D, Zhou X, Song Y, Wang Z, (2020). Effect of Short-Term Vitamin D Supplementation after Nonsurgical Periodontal Treatment: A Randomized, Double-Masked, Placebo-Controlled Clinical Trial. J. Periodont. Res; 55: 354–362.
Helal O, Göstemeyer G, Krois J, Fawzy El Sayed K, Graetz C, Schwendicke F, (2019). Predictors for tooth loss in periodontitis patients: Systematic review and meta-analysis. J. Clin. Periodontol; 46:699–712.
Iwona O and Elena F, (2022). Vitamin D3 Serum Levels in Periodontitis Patients: A Case–Control Study, Medicina (Kaunas); 58(5): 585.
Kassebaum N.J, Bernabé E, Dahiya M, Bhandari B, Murray C.J.L, Marcenes W, (2014). Global Burden of Severe Tooth Loss: A Systematic Review and Meta-analysis. JDR Clínical Res. Suppl; 93:20s–28s.
Luo PP, Xu HS, Chen YW, Wu SP, (2018). Periodontal disease severity is associated with micronutrient intake. Aust Dent J; 63(2):193–201.
Marina Peric ́, Dominique Maiter, Etienne Cavalier, Jérôme F. Lasserre and Selena Toma, (2020). The Effects of 6-Month Vitamin D Supplementation during the Non-Surgical Treatment of Periodontitis in Vitamin-D-Deficient Patients: A Randomized Double-Blind Placebo-Controlled Stud, Nutrients; 12, 2940.
Meghil M.M, Hutchens L, Raed A, Multani N.A, Rajendran M, Zhu H, Looney S, Elashiry M, Arce R.M, Peacock M.E, et al., (2019). The Influence of Vitamin D Supplementation on Local and Systemic Inflammatory Markers in Periodontitis Patients: A Pilot Study. Oral Dis; 25, 1403–1413.
Nazir M, Al-Ansari A, Al-Khalifa K, Alhareky M, Gaffar B, Almas K, (2020). The global prevalence of periodontal disease and lack of its surveillance. Sci World J; 2146160.
Pihlstrom BL, Michalowicz BS, Johnson NW, (2005). Periodontal diseases. Lancet; 366(9499):1809–20.
Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al., (2011). The report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab; 96(1):53-8.
Santonocito S, Giudice A, Polizzi A, Troiano G, Merlo E.M, Sclafani R, Grosso G, Isola G, (2022). A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis. Nutrients;14, 2426.
Sunita A, Siddharth G, Shalini S, Praneeta S, Aparajita S, Garishma G, Anmol J, (2022). Vitamin K2: An emerging essential nutraceutical and its market potential, Journal of Applied Biology & Biotechnology;10(02): 173-184.
Taskan M.M, Gevrek F, PPAR-γ, RXR, VDR, and COX-2, (2020). Expressions in gingival tissue samples of healthy individuals, periodontitis, and peri-implantitis patients. Niger. J. Clin. Pract; 23, 46–53.
Tonetti M.S, Greenwell H, Kornman K.S, (2018). Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J. Periodontol; 89 (Suppl. 1), S159–S172.
Walaa Fikry Elbossaty, (2018). Significant influence for vitamin K on metabolic disease according to a positive effect on levels of both vitamin D and calcium.pdf. Egypt: Archives of Biotechnology and Biomedicine: Heighten Science Publication; 008–11