• HARETH H. KASKOS Dept. of oral and maxillofacial surgery,College of Dentistry, University of Duhok, Kurdistan Region Iraq
  • AHMED ALI Dept. of oral and maxillofacial surgery,College of Dentistry, University of Duhok, Kurdistan Region Iraq
Keywords: MTA, Biodentine, Bone Marrow


Maxillofacial surgery employs several surgical procedures in soft and hard tissues. When hard tissues are involved, for instance, periapical surgery, cyst enucleation, tumor resection, preprosthetic surgery, when the large bony defect remaining intact it is necessary to replace by bone grafting. An in vivo and vitro studies has also shown that Mineral trioxide aggregate (MTA) and biodentine promotes both dental and bony regeneration in pulp and periradicular tissues and both have excellent biocompatibility. Materials and Methods: 20 rabbits of both sexes were enrolled in this study, three monocortical defects were created on Mandible, one considered as control and the others implanted with MTA and biodentine, on tibia, three monocortical defects were created on the same animal. Post-operative follow up date 7,14,21and 28 Days. C.T. scan was used as parameter for bone density measurement. Results: showed that non-significant difference at Day7 and14 in Mandible and significant at Day21 and 28 compared to control, While nonsignificant at Day 7 in Tibia and significant at 14 and21 post-operatively with highly significant at Day28 compared to control. Conclusion: MTA and biodentine have effect on process of osteogenesis and will facilitating when it implanted with Bone marrow.


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Accorinte ML, Holland R, and Reis A, (2008). Evaluation of mineral trioxide aggregate and calcium hydroxide cement as pulpcapping agents in human teeth. J Endod; 34:1–6. ,

Asgary S, Eghbal MJ, and Ehsani S. (2010). Periradicular regeneration after endodontic surgery with calcium-enriched mixture cement in dogs. J Endod. 36(5):837-41. doi: 10.1016/j.joen.2010.03.005.

Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, Ten Kate FJ, van Deventer SJ, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li L, van den Brink GR (Sep 2007). "Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice". Cancer Research. 67 (17): 8149–55.

Einhorn TA, Majeska RJ, Mohaideen A et al (2003) :A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair. J Bone Joint Surg Am 85- A:1425–1435.

Gallas Torreira M., Dos Santos A.A., Rodriguez Cobos M.A., Fuentes Boquete I., Crespo Abelleira A. The osteoinductive potential of MTA (Mineral Trioxide Aggregate): A histologic study in rabbits Eur J Anat, 8 (3): 101-105 (2004)

Gandolfi M. G. , Siboni F., Polimeni A. , Bossù M., Riccitiello F., Rengo S. and Prati C. (2013). In Vitro Screening of the ApatiteForming Ability, Biointeractivity and Physical Properties of a Tricalcium Silicate Material for Endodontics and Restorative Dentistry Dent. J. 1, 41-60; doi:10.3390/dj1040041

Gautschi OP, Frey SP, Zellweger R (2007) Bone morphogenetic proteins in clinical applications. ANZ J Surg 77:626–631.

Hench LL, Jones JR, Sepulveda P: 2002 Bioactive Materials for Tissue Engineering Scaffolds Imperial College Press. p. 3-19.

HiranPerinpanayagam.EbtehalAl-Rabeah: Osteoblasts interact with MTA surfaces and express Runx2.Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and EndodontologyVolume 107, Issue 4, April 2009, Pages 590-596.

Joseph M. Bojrab and Don Ray Walbron. (1997). Bone Grafting principles and techniques. In Current technique in small animals surgery (book). (4th Ed). Pp:901-910.

Ozbay G, Kitiki B, Peker S, Kargul B. Apical sealing ability of a novel material: analysis by fluig filtration technique. Acta Stomatol Croat. 2014;48(2):132–39.

Parirokh M, Torabinejad M (2010). Mineral trioxide aggregate: a comprehensive literature review—part III: clinical applications, drawbacks and mechanism of action. Journal of Endodontics , 36, 400–13.

Phillips AM (2005) Overview of the fracture healing cascade. Injury 365:S5–S7

Rayyan Mohammed Abdullah: an experimental comparative study of osseous and soft tissues responses to amalgam, mineral trioxide aggregate and biodentine. a thesis submitted to the council of college of dentistry/ university of mosul as a partial fulfilment of the requirements for the degree of master of science in oral surgery.2017

Sivaprakash Rajasekharan, (2013). The efficacy of Biodentine™ and white Mineral Trioxide Aggregate in deciduous molar pulpotomy.- A Randomized Control Trial, Msc thesis, Universiteit Gent.

S.Titsinids, G.Agrogiannis, T.Karatzas. Bone grafting material in dentoalveolar reconstruction:A comprehensive review. Japanese dental science review ,volume 55 issue I, November 2019,pages 26-32.

Ten Dijke P (2006) Bone morphogenetic protein signal transduction in bone. Curr Med Res Opin 22:S7–S11.

TORABINEJAD M, WATSON TF AND PITT FORD TR (1993). Sealing ability of a mineral trioxide aggregate when used as a root end filling material. J Endod, 19: 591-595.

How to Cite
KASKOS , H. H., & ALI, A. (2020). FACILITATING OSTEOGENSIS OF MINERAL TRIOXIDE AGGREGATE AND BIODENTINE BY AUTOGENOUS BONE MARROW. (EXPERIMENTAL STUDY ON RABBIT). Journal of Duhok University, 23(1), 144-148. https://doi.org/10.26682/sjuod.2020.23.1.15
Pure and Engineering Sciences