FACILITATING OSTEOGENESIS OF CHITOSAN WITH  AUTOGENOUS BONE MARROW (EXPERIMENTAL STUDY ON RABBITS)

HAWAR ASAAD  ZEBARI; HARETH H.  KASKOS

doi:10.26682/sjuod.2020.23.2.4

HAWAR ASAAD ZEBARI Dept. of oral and maxillofacial surgery and periodontics, College of Dentistry, University of Duhok, Kurdistan Region-Iraq
HARETH H. KASKOS Duhok polytechnic University, Kurdistan Region-Iraq

DOI: https://doi.org/10.26682/sjuod.2020.23.2.4

Keywords: Chitosan. Bone Marrow. Osteogenesis

Abstract

Bone quality is the result of a complex relationship between the intrinsic properties of the materials
that comprise the bone matrix mineralization, bone mass and the spatial distribution of the bone mass.
Chitosan has been shown to be suitable bone replacement material. To evaluate the accelerating effect of
chitosan on the bone regeneration process and assessing by CT Scan were conduct this study. Several
important biological effect of chitosan has been characterized, these are high osteoinductivity,
osteointegrability and gradual biodegrability that make it a good candidate for bone regeneration.
Materials and Methods: 20 rabbits of both sex were enrolled in this study, two monocortical defects were
created on Mandible, one considered as control and the other implanted with chitosan, other two
monocortical defects were created on Tibia on the same animal. Post-operative follow up date 7,14,21and
28 Days. C.T. scan was used as parameter for bone density measurement. Results: showed that non-
significant difference at Day7 and14 in Mandible and significant at Day21 and 28 compared to control,
While non-significant at Day 7 in Tibia and significant at 14 and 21 post-operatively with highly
significant at Day28 compared to control. Conclusion: Chitosan has ability to osteogenesis when it is used
alone and the process of osteogenesis was facilitating when it is mixed with Bone marrow.

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