EFFECT OF PLATELET RICH FIBRIN AND INJECTABLE PLATELET RICH FIBRIN ON BONE HEALING (COMPARATIVE STUDY ON SHEEP)
Abstract
Objective Aim of study: This study aims to compare the effect of the PRF , i-PRF on bone defect healing. defect
The Platelet-rich fibrin (PRF) was first developed in France by Choukroun in 2001, an autologous biomaterial was developed that consists of leucocytes and platelet-rich fibrin. (PRF) (Choukroun et al 2001A more recent iteration of platelet-rich fibrin, known as injectable platelet-rich fibrin, has been developed to be utilized in a flowable form. This variant can be prepared at varying speeds and durations. Both platelet-rich fibrin forms have the potential to aid in the regeneration of both soft and hard tissues in areas affected by damage. The presence of bone abnormalities can result in both aesthetic and functional impairments, hence rendering dental rehabilitation more challenging. The aim of this study is to histologically evaluate the process of hard tissue healing in bone defects that have been treated with platelet-rich fibrin (PRF) and its injectable version, known as i-PRF.
Results :The presence of inflammation was noted during the initial weeks following surgery, accompanied by a limited proliferation of osteoblasts in platelet-rich fibrin (PRF) compared to injectable platelet-rich fibrin (i-PRF). In the 16th week, the presence of osteoblasts and fibrosis was seen, indicating the development of new and mature bone
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References
Amiri M.A., Farshidfar N., Hamedani S. The prospective relevance of autologous platelet concentrates for the treatment of oral mucositis. Oral Oncol. 2021;122
Anitua E, Prado R, Troya M, Zalduendo M, de la Fuente M, Pino A, Muruzabal F, Orive G (2016) Implementation of a more physiological plasma rich in growth factor (PRGF) protocol: anticoagulant removal and reduction in activator concentration. Platelets 27:459– 466. doi:
Anitua E, Sánchez M, Nurden AT, Nurden P, Orive G, Andia I (2006). New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol ;24:227–34.
Castillo G.F., Miranda M.E., Bojorque J.A., Barragán K.I., García D.V. Gingival and bone tissue healing in lower third molar surgeries. Comparative study between use of platelet rich fibrin versus physiological healing. Rev Odontol Mex. 2017;21(2):e1
Choukroun J, Adda F, Schoeffler C, Vervelle A (2001). An opportunity in perioimplantology: the PRF. Implantodontie; 42:55–62.
Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients' own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg. 2018; 44(1): 87-95.
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e37-44.
Dohan, D. M., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J., Mouhyi, J., & Gogly, B. (2006). Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 101(3), e37-e44.
Liu Y., Sun X., Yu J. Platelet-rich fibrin as a bone graft material in oral and maxillofacial bone regeneration: classification and summary for better application. BioMed Res Int. 2019;2019
Miron, Richard J., et al. "Use of platelet-rich fibrin in regenerative dentistry: a systematic review." Clinical oral investigations 21 (2017): 1913-1927.
Mufti, Sonam, et al. "Comparative evaluation of platelet-rich fibrin with connective tissue grafts in the treatment of miller's class i gingival recessions." Contemporary clinical dentistry 8.4 (2017): 531.
O’Connell SM (2007). Safety issues associated with platelet-rich fibrin method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 103:587–93.
Prakash S, Thakur A. Platelet concentrates: Past, present and future. J Maxillofac Oral Surg. 2011;10:45–9
Schindeler A., McDonald M.M., Bokko P., Little D.G. Bone remodeling during fracture repair: the cellular picture. Semin. Cell Dev. Biol. 2008;19(5):459–466.
Toffler M, Toscano N, Holtzclaw D, Corso MD, Dohan DM. Introducing Choukroun's platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Implant Adv Clin Dent. 2009;1:22–31.
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