PLATELET RICH FIBRIN EFFECT VERSUS HYALURONIC ACID EFFECT ON CRITICAL BONE DEFECT HEALING,( AN EXPERIMENTAL STUDY ON SHEEP.)
Abstract
Objective :The primary objectives of this study were to assess the influence of platelet-rich fibrin (PRF) and hyaluronic acid (HA) on the process of bone healing. This evaluation involved examining their effects on tissue response, inflammation, production of granulation tissue, as well as the existence of osteoid and the formation of new bone.
Background: The present study investigates the dynamic interaction between Platelet-rich fibrin (PRF) and Hyaluronic acid (HA) within this specific setting. Platelet-rich fibrin (PRF), which has a high concentration of growth factors, has been identified as a promising alternative to conventional bone grafts. In parallel, hyaluronic acid (HA) has been recognised for its significant contribution to tissue morphogenesis and the process of bone regeneration. This study examines the collective impacts and individual contributions of these factors on the acceleration of bone repair.
Methods: The study used a total of twelve adult male sheep, who were separated into four groups consisting of three sheep each. Surgical interventions were conducted, afterwards followed by postoperative assessments at certain time intervals (1, 8, 12, and 16 weeks). The histomorphometric evaluation was conducted to assess the course of bone healing.
Results: The experimental results indicate that Platelet-Rich Fibrin (PRF) has a notable cumulative impact on bone healing as time progresses. Likewise, HA demonstrated significant advancements over subsequent phases. Nevertheless, both the PRF and HA groups exhibited statistically significant differences when compared to the control group. Conclusion: The effect of PRF is mor than HA for bone healing enhancement, potentially reshaping clinical approaches
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References
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