EFFICACY OF PLATELET RICH FIBRIN ON ANGIOGENESIS

JIYAR MOHAMMED  NAJI

doi:10.26682/sjuod.2020.23.1.18

JIYAR MOHAMMED NAJI Dept. of oral surgery,Duhok Technical Institute, University Of Poly Technique, Kurdistan Region Iraq

DOI: https://doi.org/10.26682/sjuod.2020.23.1.18

Keywords: : platelet rich fibrin, angiogenesis.

Abstract

In this experiment we used platelet-rich fibrin (L-PRF) with the protocol of its production, in this study we tried to investigate the angiogenetic efficacy of L-PRF on s soft tissue. Blood samples of 8 sheep were used to establish the protocol of the L-PRF formation to develop the work. The mucoperiosteal flaps were filled with autologous L-PRF in the mandible and maxillary jaws of the sheep.

Samples taken from the surgical sites stained with haematoxylin and eosin for diagnosis of the sections, then immunohistological tests were confirmed on these sections. We noticed that after 14 days of membranes implantation there was no significant differences between their histological sections. While in histological section of 28 days, the sections with PRF has more angiogenic effect in soft tissue with much and more organized vessels in compare with control one.

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