VITAMIN D STATUS IN PEDIATRIC PATIENTS WITH DILATED CARDIOMYOPATHY
Keywords:
Dilated cardiomyopathy, Vitamin D, Heart failure
Abstract
Child heart failure is frequently brought on by dilated cardiomyopathy and it is characterized by impaired contraction and left ventricular or biventricular dilation. Evidence from recent years has demonstrated that vitamin D is crucial in a number of cardiovascular illnesses that are now more well recognized. This study evaluated vitamin D status in pediatric patients with dilated cardiomyopathy and compared it with that of healthy controls.
This study is an observational case-control study, which included 23 patients with dilated cardiomyopathy aged less than 21 years of both genders, and a control group that included 45 healthy people who were matched for age, sex, and body mass index at the surgical specialty hospital-cardiac center in Erbil, Iraq. From each one, a blood sample was taken to evaluate the serum level of 25-hydroxyvitamin D3, parathyroid hormone, phosphorus, calcium, troponin I and creatin kinase-MB levels.
The study revealed that the mean serum vitamin D3 level and mean serum calcium were significantly lower in dilated cardiomyopathy patients than controls, and significantly higher mean serum PTH and serum creatin kinase-MB in patients than controls. The difference in serum troponin I levels was not significant between the two groups. Furthermore, the study's outcomes revealed a substantial, moderately significant negative correlation between hypovitaminosis D and the dimensions of the left ventricle's end diastole and end systole in children with dilated cardiomyopathy
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References
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Antonio, C. A., Werther, B. D. (2018). Evaluation of serum cardiac troponin I values in children less than 1 year of age. Brazilian Journal of Cardiovascular Surgery, 23(3):378-82.
Baba, Y., Kubo, T., Yamanaka, S., Hirota, T., Tanioka, K., Yamasaki, N., Sugiura, T., Kitaoka, H. (2015, May). Clinical significance of high-sensitivity cardiac troponin T in patients with dilated cardiomyopathy. International Heart Journal, 56(3):309-13. doi: 10.1536/ihj.14-335. Epub 2015 Apr 27.
Bennett, J. A., Riegel, B., Bittner, V., Nichols, J. (2002). Validity and reliability of the NYHA classes for measuring research outcomes in patients with cardiac disease. Heart Lung, 31(4):262‑70.
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., Demay, M. (2008, Oct). Vitamin D and human health: lessons from vitamin D receptor null mice. Endocrine Reviews, 29(6):726–76.
Brown, J., Nunez, S., Russell, M., Spurney, C. (2009, Aug). Hypocalcemic rickets and dilated cardiomyopathy: Case reports and review of literature. Pediatric Cardiology, 30(6):818–23.
Chen, S., Law, C. S., Grigsby, C. L., Olsen, K., Hong, T. T., Zhang, Y., Yeghiazarians, Y., Gardner, D. G. (2011, Oct). Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation, 124(17):1838–47.
Duaa, M., Osama, M., Amal, A., Manal, M., Naglaa, S. (2021). Vitamin D Status in Children with Idiopathic Dilated Cardiomyopathy. Journal of Child Science, 11:e120–4.
Fattouh, A. A., Said, R. N., El Din, N. A., Ammar, R. (2010). 649 Parathyroid Hormone (PTH) and Markers of Calcium Metabolism in Children with Congestive Heart Failure. Pediatric Research, 68:332.
Green, R. J., Samy, G., Miqdady, M. S., El-Hodhod, M., Akinyinka, O. O., Saleh, G., Haddad, J., Alsaedi, S. A., Mersal, A. Y., Edris, A., Salah, M. (2015, July). Vitamin D deficiency and insufficiency in Africa and the Middle East, despite year-round sunny days. South African Medical Journal, 105(7):603–5. doi: 10.7196/samjnew.7785.
Hershberger, R. E., Morales, A., Siegfried, J. D. (2010, Nov). Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals. Genetic Medicine, 12(11):655–67.
Holick, M. F. (2007, July). Vitamin D deficiency. The New England Journal of Medicine, 357(3):266 81. doi: 10.1056/NEJMra070553.
Jia, T., Xiaoyan, W., Moyang, Z., Zhongyi, Z., Yingfeng, L. (2017). Correlation between cardiac troponin I and dilated cardiomyopathy and mechanism analysis. Biomedical Research-India, 28(1):435-41.
Judd, S. E., Tangpricha, V. (2009, July). Vitamin D. deficiency and risk for cardiovascular disease. The American Journal of the Medical Sciences, 338(1):40–4. doi: 10.1097/MAJ.0b013e3181aaee91.
Laguardia, S. P., Dockery, B. K., Bhattacharya, S. K., Nelson, M. D., Carbone, L. D., Weber, K. T. (2006). Secondary hyperparathyroidism and hypovitaminosis D in African‑Americans with decompensated heart failure. The American Journal of the Medical Sciences, 332:112‑8.
Latini, R., Masson, S., Anand, I. S., Missov, E., Carlson, M., Vago, T., Angelici, L., Barlera, S., Parrinello, G., Maggioni, A. P., Tognoni, G., Cohn, J. N. (2007, Sep). Prognostic value of very low plasma concentrations of troponin in patients with stable chronic heart failure. Circulation, 116(11):1242-9. doi: 10.1161/CIRCULATIONAHA.106.655076. Epub 2007 Aug 13.
Li, X., Luo, R., Jiang, R., Kong, H., Tang, Y., Shu, Y., Hua, W. (2014, May). The prognostic use of serum concentrations of cardiac troponin-I, CK-MB and myoglobin in patients with idiopathic dilated cardiomyopathy. Heart Lung, 43(3):219-24.
Maiya, S., Sullivan, I., Allgrove, J., Yates, R., Malone, M., Brain, C., Archer, N., Mok, Q., Daubeney, P., Tulloh, R., Burch, M. (2008, May). Hypocalcaemia and vitamin D deficiency: an important, but preventable, cause of life-threatening infant heart failure. Heart, 94(5):581–4.
Maron, B. J., Towbin, J. A., Thiene, G., Antzelevitch, C., Corrado, D., Arnett, D., Moss, A. J., Seidman, C. E., Young, J. B. (2006, April). Contemporary definitions and classification of the cardiomyopathies: an American Heart Association scientific statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation, 113(140:1807–16.
Masson, S., Anand, I., Favero, C., Barlera, S., Vago, T., Bertocchi, F., Maggioni, A. P., Tavazzi, L., Tognoni, G., Cohn, J. N., Latini, R. (2012, Jan). Serial measurement of cardiac troponin T using a highly sensitive assay in patients with chronic heart failure: data from 2 large randomized clinical trials. Circulation, 125(2):280-8.
Miettinen, K. H., Eriksson, S., Magga, J., Tuomainen, P., Kuusisto, J., Vanninen, E. J., Turpeinen, A., Punnonen, K. R., Pettersson, K., Peuhkurinen, J. K. (2008, Aug). Clinical significance of troponin I efflux and troponin autoantibodies in patients with dilated cardiomyopathy. Journal of Cardiac Failure, 14(6):481-8. doi: 10.1016/j.cardfail.2008.02.009. Epub 2008 May 27.
Miller, W. L., Hartman, K. A., Burritt, M. F., Burnett Jr, J. C., Jaffe, A. S. (2007, May). Troponin, B-type natriuretic peptides and outcomes in severe heart failure: differences between ischemic and dilated cardiomyopathies. Clinical Cardiology, 30(5):245-50.
Nellessen, U., Goder, S., Schobre, R., Abawi, M., Hecker, H., Tschoke, S. (2006). Serial analysis of troponin I levels in patients with ischemic and nonischemic dilated cardiomyopathy. Clinical Cardiology, 29:219-24.
Priya, S., Siddiqi, Z., Karoli, R., Fatima, J., Gupta, S., Mishra, R. (2016). Study of vitamin D status in patients with dilated cardiomyopathy at a teaching hospital in North India. Journal of Cardiovascular Echography, 26(03):89–93.
Sanyal, D., Raychaudhuri, M. (2013). Infants with dilated cardiomyopathy and hypocalcemia. Indian Journal Endocrinology & Metabolism, 17:S221–3.
Schierbeck, L. L., Jensen, T. S., Bang, U., Jensen, G., Kober, L., Jensen, J. E. (2011, June). Parathyroid hormone and vitamin D-markers for cardiovascular and all cause mortality in heart failure. European Journal of Heart Failure, 13(6):626–32.
Soongswang, J., Durongpisitkul, K., Ratanarapee, S., Leowattana, W., Nana, A., Laohaprasitiporn, D., Akaniroj, S., Limpimwong, N., Kangkagate, C. (2002). Cardiac troponin T: its role in the diagnosis of clinically suspected acute myocarditis and chronic dilated cardiomyopathy in children. Pediatric Cardiology, 23(5):531-5. doi: 10.1007/pl00021005.
Tomar, M., Radhakrishnan, S., Shrivastava, S. (2010, Sep). Myocardial dysfunction due to hypocalcemia. Indian Pediatrics, 47(9):781–3.
Van Ballegooijen, A. J., Reinders, I., Visser, M., Brouwer, I. A. (2013, May). Parathyroid hormone and cardiovascular disease events: A systematic review and meta analysis of prospective studies. American Heart Journal, 165(5):655 64.
Vecchia, L. L., Mezzena, G., Zanolla, L., Paccanaro, M., Varotto, L., Bonanno, C., Ometto, R. (2000, July). Cardiac troponin I as diagnostic and prognostic marker in severe heart failure. Journal of Heart & Lung Transplantation, 19(7):644-52. doi: 10.1016/s1053-2498(00)00120-0.
Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin, E. J., D'Agostino, R. B., Wolf, M., Vasan, R. S. (2008, Jan). Vitamin D deficiency and risk of cardiovascular disease. Circulation, 117(4):503–11.
Welsh, P., Preiss, D., Hayward, C., Shah, A. S., McAllister, D., Briggs, A., Boachie, C., McConnachie, A., Padmanabhan, S., Welsh, C., Woodward, M., Campbell, A., Porteous, D., Mills, N. L., Sattar, N. (2019, June). Cardiac Troponin T and Troponin I in the General Population. Circulation, 139(24):2754-64. doi: 10.1161/CIRCULATIONAHA.118.038529. Epub 2019 Apr 24.
Yilmaz, O., Olgun, H., Ciftel, M., Kilic, O., Kartal, I., Iskenderoglu, N. Y., Laloglu, F., Ceviz, N. (2015, Feb). Dilated cardiomyopathy secondary to rickets-related hypocalcemia: eight case reports and a review of the literature. Cardiology in the Young, 25(2):261-6.
Zittermann, A., Schleithoff, S. S., Tenderich, G., Berthold, H. K., Korfer, R., Stehle, P. (2013). Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure. Journal of the American College of Cardiology, 41:105–12.
Ameri, P., Canepa, M., Milaneschi, Y., Spallarossa, P., Leoncini, G., Giallauria, F., Strait, J. B., Lakatta, E. G., Brunelli, C., Murialdo, G., Ferrucci, L. (2013, March). Relationship between vitamin D status and left ventricular geometry in a healthy population: results from the Baltimore Longitudinal Study of Aging. Journal of Internal Medicine, 273(3):253–62.
Antonio, C. A., Werther, B. D. (2018). Evaluation of serum cardiac troponin I values in children less than 1 year of age. Brazilian Journal of Cardiovascular Surgery, 23(3):378-82.
Baba, Y., Kubo, T., Yamanaka, S., Hirota, T., Tanioka, K., Yamasaki, N., Sugiura, T., Kitaoka, H. (2015, May). Clinical significance of high-sensitivity cardiac troponin T in patients with dilated cardiomyopathy. International Heart Journal, 56(3):309-13. doi: 10.1536/ihj.14-335. Epub 2015 Apr 27.
Bennett, J. A., Riegel, B., Bittner, V., Nichols, J. (2002). Validity and reliability of the NYHA classes for measuring research outcomes in patients with cardiac disease. Heart Lung, 31(4):262‑70.
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., Demay, M. (2008, Oct). Vitamin D and human health: lessons from vitamin D receptor null mice. Endocrine Reviews, 29(6):726–76.
Brown, J., Nunez, S., Russell, M., Spurney, C. (2009, Aug). Hypocalcemic rickets and dilated cardiomyopathy: Case reports and review of literature. Pediatric Cardiology, 30(6):818–23.
Chen, S., Law, C. S., Grigsby, C. L., Olsen, K., Hong, T. T., Zhang, Y., Yeghiazarians, Y., Gardner, D. G. (2011, Oct). Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation, 124(17):1838–47.
Duaa, M., Osama, M., Amal, A., Manal, M., Naglaa, S. (2021). Vitamin D Status in Children with Idiopathic Dilated Cardiomyopathy. Journal of Child Science, 11:e120–4.
Fattouh, A. A., Said, R. N., El Din, N. A., Ammar, R. (2010). 649 Parathyroid Hormone (PTH) and Markers of Calcium Metabolism in Children with Congestive Heart Failure. Pediatric Research, 68:332.
Green, R. J., Samy, G., Miqdady, M. S., El-Hodhod, M., Akinyinka, O. O., Saleh, G., Haddad, J., Alsaedi, S. A., Mersal, A. Y., Edris, A., Salah, M. (2015, July). Vitamin D deficiency and insufficiency in Africa and the Middle East, despite year-round sunny days. South African Medical Journal, 105(7):603–5. doi: 10.7196/samjnew.7785.
Hershberger, R. E., Morales, A., Siegfried, J. D. (2010, Nov). Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals. Genetic Medicine, 12(11):655–67.
Holick, M. F. (2007, July). Vitamin D deficiency. The New England Journal of Medicine, 357(3):266 81. doi: 10.1056/NEJMra070553.
Jia, T., Xiaoyan, W., Moyang, Z., Zhongyi, Z., Yingfeng, L. (2017). Correlation between cardiac troponin I and dilated cardiomyopathy and mechanism analysis. Biomedical Research-India, 28(1):435-41.
Judd, S. E., Tangpricha, V. (2009, July). Vitamin D. deficiency and risk for cardiovascular disease. The American Journal of the Medical Sciences, 338(1):40–4. doi: 10.1097/MAJ.0b013e3181aaee91.
Laguardia, S. P., Dockery, B. K., Bhattacharya, S. K., Nelson, M. D., Carbone, L. D., Weber, K. T. (2006). Secondary hyperparathyroidism and hypovitaminosis D in African‑Americans with decompensated heart failure. The American Journal of the Medical Sciences, 332:112‑8.
Latini, R., Masson, S., Anand, I. S., Missov, E., Carlson, M., Vago, T., Angelici, L., Barlera, S., Parrinello, G., Maggioni, A. P., Tognoni, G., Cohn, J. N. (2007, Sep). Prognostic value of very low plasma concentrations of troponin in patients with stable chronic heart failure. Circulation, 116(11):1242-9. doi: 10.1161/CIRCULATIONAHA.106.655076. Epub 2007 Aug 13.
Li, X., Luo, R., Jiang, R., Kong, H., Tang, Y., Shu, Y., Hua, W. (2014, May). The prognostic use of serum concentrations of cardiac troponin-I, CK-MB and myoglobin in patients with idiopathic dilated cardiomyopathy. Heart Lung, 43(3):219-24.
Maiya, S., Sullivan, I., Allgrove, J., Yates, R., Malone, M., Brain, C., Archer, N., Mok, Q., Daubeney, P., Tulloh, R., Burch, M. (2008, May). Hypocalcaemia and vitamin D deficiency: an important, but preventable, cause of life-threatening infant heart failure. Heart, 94(5):581–4.
Maron, B. J., Towbin, J. A., Thiene, G., Antzelevitch, C., Corrado, D., Arnett, D., Moss, A. J., Seidman, C. E., Young, J. B. (2006, April). Contemporary definitions and classification of the cardiomyopathies: an American Heart Association scientific statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation, 113(140:1807–16.
Masson, S., Anand, I., Favero, C., Barlera, S., Vago, T., Bertocchi, F., Maggioni, A. P., Tavazzi, L., Tognoni, G., Cohn, J. N., Latini, R. (2012, Jan). Serial measurement of cardiac troponin T using a highly sensitive assay in patients with chronic heart failure: data from 2 large randomized clinical trials. Circulation, 125(2):280-8.
Miettinen, K. H., Eriksson, S., Magga, J., Tuomainen, P., Kuusisto, J., Vanninen, E. J., Turpeinen, A., Punnonen, K. R., Pettersson, K., Peuhkurinen, J. K. (2008, Aug). Clinical significance of troponin I efflux and troponin autoantibodies in patients with dilated cardiomyopathy. Journal of Cardiac Failure, 14(6):481-8. doi: 10.1016/j.cardfail.2008.02.009. Epub 2008 May 27.
Miller, W. L., Hartman, K. A., Burritt, M. F., Burnett Jr, J. C., Jaffe, A. S. (2007, May). Troponin, B-type natriuretic peptides and outcomes in severe heart failure: differences between ischemic and dilated cardiomyopathies. Clinical Cardiology, 30(5):245-50.
Nellessen, U., Goder, S., Schobre, R., Abawi, M., Hecker, H., Tschoke, S. (2006). Serial analysis of troponin I levels in patients with ischemic and nonischemic dilated cardiomyopathy. Clinical Cardiology, 29:219-24.
Priya, S., Siddiqi, Z., Karoli, R., Fatima, J., Gupta, S., Mishra, R. (2016). Study of vitamin D status in patients with dilated cardiomyopathy at a teaching hospital in North India. Journal of Cardiovascular Echography, 26(03):89–93.
Sanyal, D., Raychaudhuri, M. (2013). Infants with dilated cardiomyopathy and hypocalcemia. Indian Journal Endocrinology & Metabolism, 17:S221–3.
Schierbeck, L. L., Jensen, T. S., Bang, U., Jensen, G., Kober, L., Jensen, J. E. (2011, June). Parathyroid hormone and vitamin D-markers for cardiovascular and all cause mortality in heart failure. European Journal of Heart Failure, 13(6):626–32.
Soongswang, J., Durongpisitkul, K., Ratanarapee, S., Leowattana, W., Nana, A., Laohaprasitiporn, D., Akaniroj, S., Limpimwong, N., Kangkagate, C. (2002). Cardiac troponin T: its role in the diagnosis of clinically suspected acute myocarditis and chronic dilated cardiomyopathy in children. Pediatric Cardiology, 23(5):531-5. doi: 10.1007/pl00021005.
Tomar, M., Radhakrishnan, S., Shrivastava, S. (2010, Sep). Myocardial dysfunction due to hypocalcemia. Indian Pediatrics, 47(9):781–3.
Van Ballegooijen, A. J., Reinders, I., Visser, M., Brouwer, I. A. (2013, May). Parathyroid hormone and cardiovascular disease events: A systematic review and meta analysis of prospective studies. American Heart Journal, 165(5):655 64.
Vecchia, L. L., Mezzena, G., Zanolla, L., Paccanaro, M., Varotto, L., Bonanno, C., Ometto, R. (2000, July). Cardiac troponin I as diagnostic and prognostic marker in severe heart failure. Journal of Heart & Lung Transplantation, 19(7):644-52. doi: 10.1016/s1053-2498(00)00120-0.
Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin, E. J., D'Agostino, R. B., Wolf, M., Vasan, R. S. (2008, Jan). Vitamin D deficiency and risk of cardiovascular disease. Circulation, 117(4):503–11.
Welsh, P., Preiss, D., Hayward, C., Shah, A. S., McAllister, D., Briggs, A., Boachie, C., McConnachie, A., Padmanabhan, S., Welsh, C., Woodward, M., Campbell, A., Porteous, D., Mills, N. L., Sattar, N. (2019, June). Cardiac Troponin T and Troponin I in the General Population. Circulation, 139(24):2754-64. doi: 10.1161/CIRCULATIONAHA.118.038529. Epub 2019 Apr 24.
Yilmaz, O., Olgun, H., Ciftel, M., Kilic, O., Kartal, I., Iskenderoglu, N. Y., Laloglu, F., Ceviz, N. (2015, Feb). Dilated cardiomyopathy secondary to rickets-related hypocalcemia: eight case reports and a review of the literature. Cardiology in the Young, 25(2):261-6.
Zittermann, A., Schleithoff, S. S., Tenderich, G., Berthold, H. K., Korfer, R., Stehle, P. (2013). Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure. Journal of the American College of Cardiology, 41:105–12.
Published
2022-11-10
How to Cite
JALALALDEEN , I. J., & MAHMOOD, N. A. (2022). VITAMIN D STATUS IN PEDIATRIC PATIENTS WITH DILATED CARDIOMYOPATHY . Journal of Duhok University, 25(2), 142-150. https://doi.org/10.26682/sjuod.2022.25.2.13
Section
Pure and Engineering Sciences
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