EFFECT OF GARLIC OIL ON SOME BIOCHEMICAL PARAMETERS IN RATS EXPOSED TO HYDROGEN PEROXIDE
Introduction: Medicinal plants have therapeutic impacts in both modern and traditional medicines. Therefore, some biochemical parameters were investigated in rats fed with garlic oil daily for three weeks.
Methods: A total of 20 healthy adult Wister albino male rats aged eight weeks and older were allocated into four equal groups as follow. Group I or control treated with normal diet and water. Group II/ administrated by 1% hydrogen peroxide (H2O2) with drinking water in a dark bottle prepared daily with normal diet. Group III administrated with 5 ml garlic oil added to 25 grams of their ratio for each rat (25oil/125g) also prepared daily with normal drinking water. Group IV also administrated with 5 ml of garlic oil added to 25 gram of their ratio with drinking water that contained1% hydrogen peroxide in a dark bottle.
Results: The subjects in the garlic group had significantly lower total cholesterol (54.30 vs. 68.90 mg/dl); VLDL (12.64 vs. 14.62 mg/dl); LDL (32.27 vs. 46.75 mg/dl); and higher HDL (9.39 vs. 7.53 mg/dl)) compared to the control group. The difference in liver and kidney parameters between the control and H2O2 + garlic was not significant. Similarly, no significant difference was found between the garlic and control group in GPT (20.23 vs. 23.38); urea (40.80 vs. 37.10); uric acid (0.53 vs. 0.59); and creatinine (0.57 vs. 0.78); except for GOT (15.80 vs. 30.04).
Conclusions: The present study showed the garlic extract is effective to reduce total cholesterol, LDL, VLDL, GOT and increase HDL levels.
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